Hypogammaglobulinemia and bacterial infections following pediatric post‐transplant lymphoproliferative disorder in the rituximab era

Hypogammaglobulinemia and bacterial infections following pediatric post‐transplant lymphoproliferative disorder in the rituximab era

Introduction Treatment of PTLD using immune‐depleting agents such as RTX may be associated with increased risk of infections. The aim of this report was to describe the incidence of hypogammaglobulinemia and bacterial infections in children with PTLD after SOT at a single center since the introducti...

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Veröffentlicht in:Pediatric transplantation 2019-09, Vol.23 (6), p.e13519-n/a
Hauptverfasser: Chiou, Fang Kuan, Beath, Sue V., Patel, Mitul, Gupte, Girish L.
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial infections
Biopsy
Hypogammaglobulinemia
immunoglobulin
Immunoglobulin G
Immunotherapy
Infections
Lymphatic diseases
Lymphocytes
lymphoproliferative disorder
Monoclonal antibodies
organ transplantation
Patients
Pediatrics
Posttransplant lymphoproliferative disorders
Rituximab
Sepsis
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Zusammenfassung:Introduction Treatment of PTLD using immune‐depleting agents such as RTX may be associated with increased risk of infections. The aim of this report was to describe the incidence of hypogammaglobulinemia and bacterial infections in children with PTLD after SOT at a single center since the introduction of RTX. Methods A retrospective review was conducted over a study period of 2000‐2016 in pediatric patients diagnosed with biopsy‐proven PTLD based on the WHO histologic criteria. Hypogammaglobulinemia was defined by serum IgG
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13519