Transition-Metal and Solvent-Free Oxidative C–H Fluoroalkoxylation of Quinoxalinones with Fluoroalkyl Alcohols

Transition-Metal and Solvent-Free Oxidative C–H Fluoroalkoxylation of Quinoxalinones with Fluoroalkyl Alcohols

The first example of oxidative C–H fluoroalkoxylation of quinoxalinones with fluoroalkyl alcohols under transition-metal and solvent-free conditions is described. This approach provides the synthesis of fluoroalkoxylated quinoxaline derivatives with good to excellent yields under mild reactions cond...

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Veröffentlicht in:Organic letters 2019-06, Vol.21 (12), p.4698-4702
Hauptverfasser: Xu, Jun, Yang, Huiyong, Cai, Heng, Bao, Hanyang, Li, Wanmei, Zhang, Pengfei
Format: Artikel
Sprache:eng
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Zusammenfassung:The first example of oxidative C–H fluoroalkoxylation of quinoxalinones with fluoroalkyl alcohols under transition-metal and solvent-free conditions is described. This approach provides the synthesis of fluoroalkoxylated quinoxaline derivatives with good to excellent yields under mild reactions conditions. This method can also be extended to the facile and efficient synthesis of histamine-4 receptor.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01578