Rhodium(III)-Catalyzed Oxidative Allylic C–H Indolylation via Nucleophilic Cyclization

Rhodium(III)-Catalyzed Oxidative Allylic C–H Indolylation via Nucleophilic Cyclization

Reported herein is a mild synthesis of 3-allylindoles via Rh­(III)-catalyzed allylic C–H activation of olefins and coupling with o-alkynylanilines. The reaction proceeded via initial nucleophilic cyclization of o-alkynylanilines followed by oxidative coupling with allylic C–H bonds via an η3-allyl i...

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Veröffentlicht in:Organic letters 2019-06, Vol.21 (12), p.4662-4666
Hauptverfasser: Sun, Jiaqiong, Wang, Kuan, Wang, Peiyuan, Zheng, Guangfan, Li, Xingwei
Format: Artikel
Sprache:eng
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Zusammenfassung:Reported herein is a mild synthesis of 3-allylindoles via Rh­(III)-catalyzed allylic C–H activation of olefins and coupling with o-alkynylanilines. The reaction proceeded via initial nucleophilic cyclization of o-alkynylanilines followed by oxidative coupling with allylic C–H bonds via an η3-allyl intermediate.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01553