Residual force enhancement and force depression in human single muscle fibres
Residual force depression (rFD) and residual force enhancement (rFE) are intrinsic contractile properties of muscle. rFD is characterized as a decrease in steady-state isometric force following active shortening compared with a purely isometric contraction at the same muscle length and level of acti...
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| Veröffentlicht in: | Journal of biomechanics 2019-06, Vol.91, p.164-169 |
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| creator | Pinnell, Rhiannan A.M. Mashouri, Parastoo Mazara, Nicole Weersink, Erin Brown, Stephen H.M. Power, Geoffrey A. |
| description | Residual force depression (rFD) and residual force enhancement (rFE) are intrinsic contractile properties of muscle. rFD is characterized as a decrease in steady-state isometric force following active shortening compared with a purely isometric contraction at the same muscle length and level of activation. By contrast, isometric force is increased following active lengthening compared to a reference isometric contraction at the same muscle length and level of activation; this is termed rFE. To date, there have been no investigations of rFD and rFE in human muscle fibres, therefore the purpose of this study was to determine whether rFD and rFE occur at the single muscle fibre level in humans. rFD and rFE were investigated in maximally activated single muscle fibres biopsied from the vastus lateralis of healthy adults. To induce rFD, fibres were activated and shortened from an average sarcomere length (SL) of 3.2–2.6 μm. Reference isometric contractions were performed at an average SL of 2.6 μm. To induce rFE, fibres were actively lengthened from an average SL of 2.6–3.2 μm and a reference isometric contraction was performed at an average SL of 3.2 μm. Isometric steady-state force was lower following active shortening (p |
| doi_str_mv | 10.1016/j.jbiomech.2019.05.025 |
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By contrast, isometric force is increased following active lengthening compared to a reference isometric contraction at the same muscle length and level of activation; this is termed rFE. To date, there have been no investigations of rFD and rFE in human muscle fibres, therefore the purpose of this study was to determine whether rFD and rFE occur at the single muscle fibre level in humans. rFD and rFE were investigated in maximally activated single muscle fibres biopsied from the vastus lateralis of healthy adults. To induce rFD, fibres were activated and shortened from an average sarcomere length (SL) of 3.2–2.6 μm. Reference isometric contractions were performed at an average SL of 2.6 μm. To induce rFE, fibres were actively lengthened from an average SL of 2.6–3.2 μm and a reference isometric contraction was performed at an average SL of 3.2 μm. Isometric steady-state force was lower following active shortening (p < 0.05), and higher following active lengthening (p < 0.05), as compared to the reference isometric contractions. We demonstrated rFD and rFE in human single fibres which is consistent with previous animal models. The non-responder phenomenon often reported in rFE studies involving voluntary contractions at the whole human level was not observed at the single fibre level.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2019.05.025</identifier><identifier>PMID: 31155213</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Activation ; Animal models ; Contraction ; Cross-bridge cycling ; Fibers ; Force depression ; History-dependence of force ; MHC ; Muscle contraction ; Muscles ; Passive force enhancement ; Production capacity ; Residual force enhancement ; Single fibre ; Steady state ; Stiffness ; Studies</subject><ispartof>Journal of biomechanics, 2019-06, Vol.91, p.164-169</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>2019. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-e47442d05e259deebf6d406fae15b385cb0721f181658a7d78a3e98031a0e8d53</citedby><cites>FETCH-LOGICAL-c444t-e47442d05e259deebf6d406fae15b385cb0721f181658a7d78a3e98031a0e8d53</cites><orcidid>0000-0003-4007-0014</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2239146867?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31155213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinnell, Rhiannan A.M.</creatorcontrib><creatorcontrib>Mashouri, Parastoo</creatorcontrib><creatorcontrib>Mazara, Nicole</creatorcontrib><creatorcontrib>Weersink, Erin</creatorcontrib><creatorcontrib>Brown, Stephen H.M.</creatorcontrib><creatorcontrib>Power, Geoffrey A.</creatorcontrib><title>Residual force enhancement and force depression in human single muscle fibres</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>Residual force depression (rFD) and residual force enhancement (rFE) are intrinsic contractile properties of muscle. rFD is characterized as a decrease in steady-state isometric force following active shortening compared with a purely isometric contraction at the same muscle length and level of activation. By contrast, isometric force is increased following active lengthening compared to a reference isometric contraction at the same muscle length and level of activation; this is termed rFE. To date, there have been no investigations of rFD and rFE in human muscle fibres, therefore the purpose of this study was to determine whether rFD and rFE occur at the single muscle fibre level in humans. rFD and rFE were investigated in maximally activated single muscle fibres biopsied from the vastus lateralis of healthy adults. To induce rFD, fibres were activated and shortened from an average sarcomere length (SL) of 3.2–2.6 μm. Reference isometric contractions were performed at an average SL of 2.6 μm. To induce rFE, fibres were actively lengthened from an average SL of 2.6–3.2 μm and a reference isometric contraction was performed at an average SL of 3.2 μm. Isometric steady-state force was lower following active shortening (p < 0.05), and higher following active lengthening (p < 0.05), as compared to the reference isometric contractions. We demonstrated rFD and rFE in human single fibres which is consistent with previous animal models. The non-responder phenomenon often reported in rFE studies involving voluntary contractions at the whole human level was not observed at the single fibre level.</description><subject>Activation</subject><subject>Animal models</subject><subject>Contraction</subject><subject>Cross-bridge cycling</subject><subject>Fibers</subject><subject>Force depression</subject><subject>History-dependence of force</subject><subject>MHC</subject><subject>Muscle contraction</subject><subject>Muscles</subject><subject>Passive force enhancement</subject><subject>Production capacity</subject><subject>Residual force enhancement</subject><subject>Single fibre</subject><subject>Steady state</subject><subject>Stiffness</subject><subject>Studies</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1r3DAQhkVJabZJ_0Iw5JKL3dGXJd9aQtoGUgqlOQtZGndlbHkrrQv999Gymxx6yWlgeN53hoeQKwoNBdp-HJuxD8uMbtswoF0DsgEm35AN1YrXjGs4IxsARuuOdXBO3uc8AoASqntHzjmlUjLKN-T7T8zBr3aqhiU5rDBubXQ4Y9xXNvrT1uMuYc5hiVWI1XadbaxyiL8nrOY1uzKG0Bfikrwd7JTxw2lekMcvd79uv9UPP77e335-qJ0QYl-jUEIwDxKZ7DxiP7ReQDtYpLLnWroeFKMD1bSV2iqvtOXYaeDUAmov-QW5Ofbu0vJnxbw3c8gOp8lGXNZsGONCaNVCV9Dr_9BxWVMs3x2ojopWt6pQ7ZFyack54WB2Kcw2_TMUzEG4Gc2zcHMQbkCaIrwEr071az-jf4k9Gy7ApyOAxcffgMlkF7Ao9iGh2xu_hNduPAHhPZQE</recordid><startdate>20190625</startdate><enddate>20190625</enddate><creator>Pinnell, Rhiannan A.M.</creator><creator>Mashouri, Parastoo</creator><creator>Mazara, Nicole</creator><creator>Weersink, Erin</creator><creator>Brown, Stephen H.M.</creator><creator>Power, Geoffrey A.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4007-0014</orcidid></search><sort><creationdate>20190625</creationdate><title>Residual force enhancement and force depression in human single muscle fibres</title><author>Pinnell, Rhiannan A.M. ; 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By contrast, isometric force is increased following active lengthening compared to a reference isometric contraction at the same muscle length and level of activation; this is termed rFE. To date, there have been no investigations of rFD and rFE in human muscle fibres, therefore the purpose of this study was to determine whether rFD and rFE occur at the single muscle fibre level in humans. rFD and rFE were investigated in maximally activated single muscle fibres biopsied from the vastus lateralis of healthy adults. To induce rFD, fibres were activated and shortened from an average sarcomere length (SL) of 3.2–2.6 μm. Reference isometric contractions were performed at an average SL of 2.6 μm. To induce rFE, fibres were actively lengthened from an average SL of 2.6–3.2 μm and a reference isometric contraction was performed at an average SL of 3.2 μm. Isometric steady-state force was lower following active shortening (p < 0.05), and higher following active lengthening (p < 0.05), as compared to the reference isometric contractions. We demonstrated rFD and rFE in human single fibres which is consistent with previous animal models. The non-responder phenomenon often reported in rFE studies involving voluntary contractions at the whole human level was not observed at the single fibre level.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>31155213</pmid><doi>10.1016/j.jbiomech.2019.05.025</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4007-0014</orcidid></addata></record> |
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| subjects | Activation Animal models Contraction Cross-bridge cycling Fibers Force depression History-dependence of force MHC Muscle contraction Muscles Passive force enhancement Production capacity Residual force enhancement Single fibre Steady state Stiffness Studies |
| title | Residual force enhancement and force depression in human single muscle fibres |
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