Age, gender and efflux transporter activity influence imatinib efficacy in chronic myeloid leukemia patients

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Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2019-07, Vol.82, p.33-35
Hauptverfasser:	Vasconcelos, Flavia C., Bonecker, Simone T., de Souza, Paloma S., Scheiner, Marcos Antonio Mauricio, Amaral, Natalia, Zalcberg, Ilana, Thuler, Luiz Claudio S., Maia, Raquel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Antineoplastic Agents - metabolism Antineoplastic Agents - therapeutic use ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism B-Lymphocytes - drug effects B-Lymphocytes - metabolism B-Lymphocytes - pathology Biological Transport Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Female Humans Imatinib Mesylate - metabolism Imatinib Mesylate - therapeutic use K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Male Middle Aged Primary Cell Culture Progesterone - pharmacology Proto-Oncogene Proteins c-abl - genetics Proto-Oncogene Proteins c-abl - metabolism Sex Factors Treatment Outcome
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