Novel 4-methoxynaphthalene- N -acylhydrazones as potential for paracoccidioidomycosis and tuberculosis co-infection

17 new 4-methoxynaphthalene- -acylhydrazones were synthesized in order to evaluate their biological action against important pathogens. susceptibility assays of compounds were performed against and . Compounds , and were the most potent against , two with minimum inhibitory concentrations of ≤1 μg ml and exhibited pharmacological synergy with amphotericin B. The compounds also showed activity against , with and being the more promising. Compound showed good synergistic antimycobacterium activity with ethambutol. None of the compounds tested showed toxicity. We highlight the compound , as a potential agent for the treatment of patients co-infected with paracoccidioidomycosis and tuberculosis.