Discordance between the QuantiFERON Gold In-Tube and QuantiFERON Gold Plus assays associated with country of birth TB incidence

Discordance between the QuantiFERON Gold In-Tube and QuantiFERON Gold Plus assays associated with country of birth TB incidence

The new QuantiFERON Gold Plus (QFT+) assay is used for diagnosing tuberculosis (TB) infection and has 2 phlebotomy methods: direct (QFT + D) and single tube transfer (QFT + T). Little data is available on how the TB incidence in the country of birth (COB) of healthcare workers (HCWs) can impact the...

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Veröffentlicht in:Tuberculosis (Edinburgh, Scotland) Scotland), 2019-05, Vol.116, p.S2-S10
Hauptverfasser: Agarwal, Saroochi, Nguyen, Duc T., Lew, Justin D., Graviss, Edward A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Agreement
Enzyme-Linked Immunosorbent Assay
Female
Foreign Professional Personnel
Health Personnel
Humans
IGRA
Incidence
Interferon-gamma Release Tests - methods
Male
Middle Aged
Occupational Health
Phlebotomy
Predictive Value of Tests
QuantiFERON gold plus
Reproducibility of Results
Residence Characteristics
Tuberculosis - blood
Tuberculosis - diagnosis
Tuberculosis - ethnology
Tuberculosis - microbiology
Tuberculosis incidence
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Zusammenfassung:The new QuantiFERON Gold Plus (QFT+) assay is used for diagnosing tuberculosis (TB) infection and has 2 phlebotomy methods: direct (QFT + D) and single tube transfer (QFT + T). Little data is available on how the TB incidence in the country of birth (COB) of healthcare workers (HCWs) can impact the assay results. QuantiFERON Gold In-Tube (QFT-G), QFT + D and QFT + T assays were obtained from a single blood draw and compared for HCWs annually tested for TB infection. HCWs COB was ranked as: high (≥150 per 100,000), medium (20–149), and low TB incidence (
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2019.04.005