Interferon‐Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non‐human primates

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non‐human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon‐gamma release. Initial evaluation using blood samples from Rhesus macaques experime...

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Veröffentlicht in:	Journal of medical primatology 2019-08, Vol.48 (4), p.260-263
Hauptverfasser:	Yee, JoAnn L., Prongay, Kamm, Miles, Brodie, Smedley, Jeremy, Hansen, Scott G., Axthelm, Michael K., Ardeshir, Amir, Van Rompay, Koen K. A., Timmel, Gregory, Roberts, Jeffrey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell‐mediated immune response (CMI) Enzyme-Linked Immunosorbent Assay - methods Enzyme-Linked Immunosorbent Assay - veterinary Immune response Interferon Interferon-gamma Release Tests - methods Interferon-gamma Release Tests - veterinary interferon‐gamma release assay (IGRA) Macaca mulatta Monkey Diseases - diagnosis Mycobacterium tuberculosis Mycobacterium tuberculosis - isolation & purification purified protein derivative—tuberculin (PPD) Tuberculosis Tuberculosis - diagnosis
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Beschreibung
Zusammenfassung:	We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non‐human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon‐gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.
ISSN:	0047-2565 1600-0684
DOI:	10.1111/jmp.12420