Polyethylene glycol (PEG-400) promoted one-pot, five-component synthesis of (E)-ethyl2-(2-((E)-2-(1-(4-methyl-2-(phenylamino)thiazol-5yl)ethylidene)hydrazinyl)-4-oxothiazol-5(4H)-ylidene)acetates

A facile, inexpensive and eco-friendly synthesis of functionalised (E)-ethyl2-(2-((E)-2-(1-(4-methyl-2-(phenylamino)thiazol-5yl)ethylidene)hydrazinyl)14-oxothiazol-5(4 H )-ylidene)acetates has been developed via one-pot five-component approach. The title compounds were synthesized by the reaction of...

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Veröffentlicht in:	Molecular diversity 2020-05, Vol.24 (2), p.413-421
Hauptverfasser:	Sujatha, Kodam, Vedula, Rajeswar Rao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemical synthesis Aniline Compounds - chemistry Biochemistry Biomedical and Life Sciences Carboxylic Acids - chemistry Green Chemistry Technology Life Sciences Organic Chemistry Original Article Pentanes - chemistry Pharmacy Polyethylene glycol Polyethylene Glycols - chemistry Polymer Sciences Semicarbazides - chemistry Solvents - chemistry Thiocyanates - chemistry
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Zusammenfassung:	A facile, inexpensive and eco-friendly synthesis of functionalised (E)-ethyl2-(2-((E)-2-(1-(4-methyl-2-(phenylamino)thiazol-5yl)ethylidene)hydrazinyl)14-oxothiazol-5(4 H )-ylidene)acetates has been developed via one-pot five-component approach. The title compounds were synthesized by the reaction of anilines, 3-chloropentane-2,4-dione, ammoniumthiocyanate, thiosemicarbazide and dialkylacetylene dicarboxylate using polyethylene glycol as green and recyclable solvent. The domino reaction proceeded smoothly in good-to-excellent yields. Graphical abstract
ISSN:	1381-1991 1573-501X
DOI:	10.1007/s11030-019-09962-3