Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

Objective Periodontitis is an inflammatory disease that is a result of the interaction between pathogenic bacteria and host immune response. Genetic alterations in interleukin‐10 (IL‐10) gene may be associated with the increased risk of periodontitis. We investigated the association between genotype and haplotype frequencies of IL‐10 gene polymorphisms and susceptibility to periodontitis in an Iranian population. Methods In this case–control study, a total of 64 patients with periodontitis and 128 healthy subjects were recruited. The PCR‐RFLP technique was used to detect IL‐10 promoter genotypes at the positions of ‐1082 (G/A), ‐819 (C/T), and ‐592 (C/A) in association with the susceptibility to severe chronic periodontitis. Results Regarding IL‐10 ‐592 (C/A) and IL‐10 ‐819 (C/T) alleles and genotypes, no significant association was observed between the risk of periodontitis and genotype frequencies. However, the frequency of GG genotype in IL‐10 ‐1082 (G/A) polymorphic region was higher in normal subjects and was associated with the decreased risk of periodontitis under recessive model [OR = 2.89, 95% CI (0.99–8.43), p = 0.039]. Haplotype analysis revealed a significantly higher presence of H7 (AGC; ‐592/‐1082/‐819) [OR = 97.74, 95% CI (95.52–99.96), p