Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany

Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany

Abstract Aims Pulmonary embolism (PE) is the third most common cardiovascular cause of death; systemic thrombolysis is potentially lifesaving treatment in patients presenting with haemodynamic instability. We investigated trends in the use of systemic thrombolysis and the outcome of patients with ac...

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Veröffentlicht in:European heart journal 2020-01, Vol.41 (4), p.522-529
Hauptverfasser: Keller, Karsten, Hobohm, Lukas, Ebner, Matthias, Kresoja, Karl-Patrik, Münzel, Thomas, Konstantinides, Stavros V, Lankeit, Mareike
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Aged
Aged, 80 and over
Female
Fibrinolytic Agents - therapeutic use
Follow-Up Studies
Germany - epidemiology
Hospital Mortality - trends
Humans
Male
Middle Aged
Pulmonary Embolism - mortality
Pulmonary Embolism - therapy
Retrospective Studies
Risk Factors
Thrombolytic Therapy - methods
Time Factors
Treatment Outcome
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Zusammenfassung:Abstract Aims Pulmonary embolism (PE) is the third most common cardiovascular cause of death; systemic thrombolysis is potentially lifesaving treatment in patients presenting with haemodynamic instability. We investigated trends in the use of systemic thrombolysis and the outcome of patients with acute PE. Methods and results We analysed data on the characteristics, comorbidities, treatment, and in-hospital outcome of 885 806 PE patients in Germany between 2005 and 2015. Incidence of acute PE was 99/100 000 population/year and increased from 85/100 000 in 2005 to 109/100 000 in 2015 [β 0.32 (0.26–0.38), P 
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehz236