Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease

[Display omitted] Parkinson’s disease (PD) is associated with symptoms such as tremor and bradykinesia which, together with a rigorous dosing regimen, can place an untenable burden on patients. These issues underscore the need for triggerable, modulated drug delivery systems. Currently, pramipexole...

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Veröffentlicht in:European journal of pharmaceutics and biopharmaceutics 2019-08, Vol.141, p.1-11
Hauptverfasser: Li, Shuang, Liu, Jiaxin, Li, Ge, Zhang, Xueyan, Xu, Fei, Fu, Zhijiang, Teng, Lesheng, Li, Youxin, Sun, Fengying
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container_title European journal of pharmaceutics and biopharmaceutics
container_volume 141
creator Li, Shuang
Liu, Jiaxin
Li, Ge
Zhang, Xueyan
Xu, Fei
Fu, Zhijiang
Teng, Lesheng
Li, Youxin
Sun, Fengying
description [Display omitted] Parkinson’s disease (PD) is associated with symptoms such as tremor and bradykinesia which, together with a rigorous dosing regimen, can place an untenable burden on patients. These issues underscore the need for triggerable, modulated drug delivery systems. Currently, pramipexole (PRX) is the most widely used non-ergot dopamine agonist for the treatment of PD. In this study, near-infrared light-responsive PRX and hollow gold nanospheres (HGNS)-loaded biodegradable poly (D, L-lactide-co-glycolide) (PLGA) microspheres (PRX/HGNS MS) were fabricated using solid-in-oil-in-water (S/O/W) and water-in-oil-in-water (W/O/W) emulsion-solvent evaporation techniques to achieve modulated drug release. The PRX/HGNS MS were uniform, with an average diameter of approximately 24 µm, favorable PRX and HGNS encapsulation efficiencies (51.71 ± 0.54% and 65.15 ± 2.30%, respectively) and rapid, controllable drug release both in vitro and in vivo. Cytotoxicity tests revealed no significant differences between HGNS and PRX/HGNS MS when compared with a negative control. Pharmacodynamics and immunohistochemistry studies revealed a more rapid recovery of striatum in the group treated with PRX/HGNS MS produced using the S/O/W method. The results clearly demonstrate that light-responsive PRX/HGNS MS produced using the S/O/W method have the potential to address PD patients’ mobility problems in a smart, controllable and remotely triggerable manner.
doi_str_mv 10.1016/j.ejpb.2019.05.013
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These issues underscore the need for triggerable, modulated drug delivery systems. Currently, pramipexole (PRX) is the most widely used non-ergot dopamine agonist for the treatment of PD. In this study, near-infrared light-responsive PRX and hollow gold nanospheres (HGNS)-loaded biodegradable poly (D, L-lactide-co-glycolide) (PLGA) microspheres (PRX/HGNS MS) were fabricated using solid-in-oil-in-water (S/O/W) and water-in-oil-in-water (W/O/W) emulsion-solvent evaporation techniques to achieve modulated drug release. The PRX/HGNS MS were uniform, with an average diameter of approximately 24 µm, favorable PRX and HGNS encapsulation efficiencies (51.71 ± 0.54% and 65.15 ± 2.30%, respectively) and rapid, controllable drug release both in vitro and in vivo. Cytotoxicity tests revealed no significant differences between HGNS and PRX/HGNS MS when compared with a negative control. Pharmacodynamics and immunohistochemistry studies revealed a more rapid recovery of striatum in the group treated with PRX/HGNS MS produced using the S/O/W method. The results clearly demonstrate that light-responsive PRX/HGNS MS produced using the S/O/W method have the potential to address PD patients’ mobility problems in a smart, controllable and remotely triggerable manner.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2019.05.013</identifier><identifier>PMID: 31100429</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Hollow gold nanospheres ; Microspheres ; Near-infrared responsive ; Parkinson’s disease ; Pramipexole</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2019-08, Vol.141, p.1-11</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. 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These issues underscore the need for triggerable, modulated drug delivery systems. Currently, pramipexole (PRX) is the most widely used non-ergot dopamine agonist for the treatment of PD. In this study, near-infrared light-responsive PRX and hollow gold nanospheres (HGNS)-loaded biodegradable poly (D, L-lactide-co-glycolide) (PLGA) microspheres (PRX/HGNS MS) were fabricated using solid-in-oil-in-water (S/O/W) and water-in-oil-in-water (W/O/W) emulsion-solvent evaporation techniques to achieve modulated drug release. The PRX/HGNS MS were uniform, with an average diameter of approximately 24 µm, favorable PRX and HGNS encapsulation efficiencies (51.71 ± 0.54% and 65.15 ± 2.30%, respectively) and rapid, controllable drug release both in vitro and in vivo. Cytotoxicity tests revealed no significant differences between HGNS and PRX/HGNS MS when compared with a negative control. Pharmacodynamics and immunohistochemistry studies revealed a more rapid recovery of striatum in the group treated with PRX/HGNS MS produced using the S/O/W method. The results clearly demonstrate that light-responsive PRX/HGNS MS produced using the S/O/W method have the potential to address PD patients’ mobility problems in a smart, controllable and remotely triggerable manner.</description><subject>Hollow gold nanospheres</subject><subject>Microspheres</subject><subject>Near-infrared responsive</subject><subject>Parkinson’s disease</subject><subject>Pramipexole</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQhi3UCrbAH-ih8q0cmjC243xIXBBqaaUVcICz5cRj8JLEwU5QOfDf8Wqhx55mDs_7juYh5CuDnAErTzc5bqY258CaHGQOTOyRFasrkYmiYJ_IChrRZGXB2AH5EuMGAIpK1vvkQDCWdt6syOsV6pC50QYd0NDe3T_MWcA4-TG6Z_xBp6AHN-Ff32PWe20S1Dpv8D5oo9se6c368pwOrgs-Tg-YotT6QOe06gmX2XV0iUjdSG90eHRj9OP3SI2LqCMekc9W9xGP3-chufv18_bid7a-vvxzcb7OOiHLOUtXuS1E1RbGVk1rGw26LNGUstI1gwqQV20tGdi20EYmgltmsOHQsapBKQ7Jya53Cv5pwTirwcUO-16P6JeoOBccRClrkVC-Q7cPxYBWTcENOrwoBmqrXW3UVrvaalcgVdKeQt_e-5d2QPMv8uE5AWc7ANOXzw6Dip3DsUPjAnazMt79r_8NWq2WQA</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Li, Shuang</creator><creator>Liu, Jiaxin</creator><creator>Li, Ge</creator><creator>Zhang, Xueyan</creator><creator>Xu, Fei</creator><creator>Fu, Zhijiang</creator><creator>Teng, Lesheng</creator><creator>Li, Youxin</creator><creator>Sun, Fengying</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease</title><author>Li, Shuang ; Liu, Jiaxin ; Li, Ge ; Zhang, Xueyan ; Xu, Fei ; Fu, Zhijiang ; Teng, Lesheng ; Li, Youxin ; Sun, Fengying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ade2f437b4df79bf9a0a66ed657a81070e27b8510fb4ad59bf2f1de920c179e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Hollow gold nanospheres</topic><topic>Microspheres</topic><topic>Near-infrared responsive</topic><topic>Parkinson’s disease</topic><topic>Pramipexole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shuang</creatorcontrib><creatorcontrib>Liu, Jiaxin</creatorcontrib><creatorcontrib>Li, Ge</creatorcontrib><creatorcontrib>Zhang, Xueyan</creatorcontrib><creatorcontrib>Xu, Fei</creatorcontrib><creatorcontrib>Fu, Zhijiang</creatorcontrib><creatorcontrib>Teng, Lesheng</creatorcontrib><creatorcontrib>Li, Youxin</creatorcontrib><creatorcontrib>Sun, Fengying</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shuang</au><au>Liu, Jiaxin</au><au>Li, Ge</au><au>Zhang, Xueyan</au><au>Xu, Fei</au><au>Fu, Zhijiang</au><au>Teng, Lesheng</au><au>Li, Youxin</au><au>Sun, Fengying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2019-08</date><risdate>2019</risdate><volume>141</volume><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>[Display omitted] Parkinson’s disease (PD) is associated with symptoms such as tremor and bradykinesia which, together with a rigorous dosing regimen, can place an untenable burden on patients. These issues underscore the need for triggerable, modulated drug delivery systems. Currently, pramipexole (PRX) is the most widely used non-ergot dopamine agonist for the treatment of PD. In this study, near-infrared light-responsive PRX and hollow gold nanospheres (HGNS)-loaded biodegradable poly (D, L-lactide-co-glycolide) (PLGA) microspheres (PRX/HGNS MS) were fabricated using solid-in-oil-in-water (S/O/W) and water-in-oil-in-water (W/O/W) emulsion-solvent evaporation techniques to achieve modulated drug release. The PRX/HGNS MS were uniform, with an average diameter of approximately 24 µm, favorable PRX and HGNS encapsulation efficiencies (51.71 ± 0.54% and 65.15 ± 2.30%, respectively) and rapid, controllable drug release both in vitro and in vivo. Cytotoxicity tests revealed no significant differences between HGNS and PRX/HGNS MS when compared with a negative control. Pharmacodynamics and immunohistochemistry studies revealed a more rapid recovery of striatum in the group treated with PRX/HGNS MS produced using the S/O/W method. The results clearly demonstrate that light-responsive PRX/HGNS MS produced using the S/O/W method have the potential to address PD patients’ mobility problems in a smart, controllable and remotely triggerable manner.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31100429</pmid><doi>10.1016/j.ejpb.2019.05.013</doi><tpages>11</tpages></addata></record>
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subjects Hollow gold nanospheres
Microspheres
Near-infrared responsive
Parkinson’s disease
Pramipexole
title Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease
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