Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at l...

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Veröffentlicht in:Infection control and hospital epidemiology 2019-07, Vol.40 (7), p.804-806
Hauptverfasser: Jakharia, Kunal K, Ilaiwy, Ghassan, Moose, Siobhan S, Waga, Masashi, Appalla, Lakshmi, McAlduff, Joel D, Karanfil, Lynne V, McGann, Patrick T, Wortmann, Glenn W
Format: Artikel
Sprache:eng
Schlagworte:
Clostridium difficile - genetics
Clostridium difficile - isolation & purification
Clostridium Infections - diagnosis
Clostridium Infections - transmission
Cross Infection - diagnosis
Cross Infection - microbiology
Cross Infection - transmission
Diarrhea
Epidemiology
Genome, Bacterial
Genomes
Health Facilities
Hospitals
Humans
Infections
Laboratories
Medical diagnosis
Nursing
Patients
Phylogenetics
Ribotyping
Software
Whole Genome Sequencing
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Zusammenfassung:Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at large, urban hospital.
ISSN:0899-823X
1559-6834
DOI:10.1017/ice.2019.124