In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field d...

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Veröffentlicht in:	Radiotherapy and oncology 2019-08, Vol.137, p.125-129
Hauptverfasser:	Nagle, Peter W., van Goethem, Marc-Jan, Kempers, Marco, Kiewit, Harry, Knopf, Antje, Langendijk, Johannes A., Brandenburg, Sytze, van Luijk, Peter, Coppes, Rob P.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenocarcinoma of Lung - radiotherapy Adenocarcinoma of Lung - therapy Animals Female HEK293 Cells Humans Magnetic Field Therapy - methods Magnetic Resonance Imaging - methods Mice Mice, Inbred C57BL MRI Normal tissue Organoids Proton Therapy - methods Protons Salivary Glands - cytology Salivary Glands - radiation effects Stem Cells - cytology Stem Cells - radiation effects Tumor
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Beschreibung
Zusammenfassung:	To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response.
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2019.04.028