Yap in regeneration and symmetry breaking

Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of intestinal regeneration and tissue organization: transient expansion of a rare cell type after damage in vivo and Notch–Dll activation for sym...

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Veröffentlicht in:	Nature cell biology 2019-06, Vol.21 (6), p.665-667
1. Verfasser:	Li, Vivian S. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2060 631/136/532/2437 631/532/489 Analysis Biomedical and Life Sciences Broken symmetry Cancer Research Cell Biology Developmental Biology Homeostasis Intestine Life Sciences News & Views news-and-views Organoids Regeneration Regeneration (Biology) Stem Cells Symmetry (Biology) Yes-associated protein
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Beschreibung
Zusammenfassung:	Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of intestinal regeneration and tissue organization: transient expansion of a rare cell type after damage in vivo and Notch–Dll activation for symmetry breaking in organoid development.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/s41556-019-0334-1