Measles virus neutralizing antibodies in immunoglobulin lots produced from plasma collected in Europe or the United States

•Analysis of >1000 of intravenous immunoglobulins (IVIGs) from EU or US plasma•IVIGs from US or EU plasma contain similar levels of measles virus antibodies.•Measles post-exposure prophylaxis in EU could be aligned with US recommendations. Vaccination against measles has reduced disease, although measles virus antibody (MVAb) levels are lower after vaccination than natural infection. Immunoglobulin (IG) preparations thus contain decreasing MVAb titers. US IG lot release requires a minimum titer of MVAb, yet equivalent information is not available for other geographies. Using a measles virus neutralization assay, IG fractionated from US or EU plasma is shown to contain similar levels of MVAb always above US regulatory requirements, supportive of equivalent protection against MV infection. Thus, the dosage for post-exposure prophylaxis in the EU could be aligned with the US FDA’s treatment recommendations.