Pregnancy outcomes in mixed connective tissue disease: a multicentre study

Abstract Objectives In this study we aimed to investigate foetal and maternal pregnancy outcomes from a large multicentre cohort of women diagnosed with MCTD and anti-U1RNP antibodies. Methods This multicentre retrospective cohort study describes the outcomes of 203 pregnancies in 94 consecutive wom...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2019-11, Vol.58 (11), p.2000-2008
Hauptverfasser:	Radin, Massimo, Schreiber, Karen, Cuadrado, Maria José, Cecchi, Irene, Andreoli, Laura, Franceschini, Franco, Caleiro, Teresa, Andrade, Danieli, Gibbone, Elena, Khamashta, Munther, Buyon, Jill, Izmirly, Peter, Aguirre, Maria Angeles, Benedetto, Chiara, Roccatello, Dario, Marozio, Luca, Sciascia, Savino
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous - epidemiology Abortion, Spontaneous - immunology Adult Autoantibodies - blood Diabetes, Gestational - epidemiology Diabetes, Gestational - immunology Female Fetal Growth Retardation - immunology Heart Block - congenital Heart Block - immunology Humans Hypertension, Pregnancy-Induced - epidemiology Hypertension, Pregnancy-Induced - immunology Infant, Newborn Live Birth - epidemiology Lupus Erythematosus, Systemic - congenital Lupus Erythematosus, Systemic - immunology Mixed Connective Tissue Disease - complications Mixed Connective Tissue Disease - immunology Pregnancy Pregnancy Complications - blood Pregnancy Complications - immunology Pregnancy Outcome Retrospective Studies Ribonucleoprotein, U1 Small Nuclear - immunology Stillbirth - epidemiology
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Zusammenfassung:	Abstract Objectives In this study we aimed to investigate foetal and maternal pregnancy outcomes from a large multicentre cohort of women diagnosed with MCTD and anti-U1RNP antibodies. Methods This multicentre retrospective cohort study describes the outcomes of 203 pregnancies in 94 consecutive women ever pregnant who fulfilled the established criteria for MCTD with confirmed U1RNP positivity. Results The foetal outcomes in 203 pregnancies were as follows: 146 (71.9%) live births, 38 (18.7%) miscarriages (first trimester pregnancy loss of
ISSN:	1462-0324 1462-0332
DOI:	10.1093/rheumatology/kez141