MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma

MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms. Thi...

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Veröffentlicht in:	Cancer letters 2019-08, Vol.456, p.40-48
Hauptverfasser:	Kao, Yu-Yu, Chou, Chung-Hsien, Yeh, Li-Yin, Chen, Yi-Fen, Chang, Kuo-Wei, Liu, Chung-Ji, Fan Chiang, Chun-Yu, Lin, Shu-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carcinoma Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Dehydrogenases Disruption Energy Metabolism Epidermal growth factor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene regulation Glycolysis Homeostasis Humans Male Medical prognosis Membrane potential Metabolism Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-31 miRNA Mitochondria Mitochondria - enzymology Mitochondria - pathology Mouth Neoplasms - enzymology Mouth Neoplasms - genetics Mouth Neoplasms - pathology NAD Neoplasia Neoplasm Invasiveness Oral Oral cancer Oral carcinoma Oral squamous cell carcinoma Oxidative Stress Pathogenesis Phosphorylation Polymerase chain reaction Post-transcription Proteins Signal Transduction SIRT3 Sirtuin 3 - genetics Sirtuin 3 - metabolism Smoking Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - enzymology Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Tumor cells Tumors
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