MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma
MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms. Thi...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2019-08, Vol.456, p.40-48 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 48 |
|---|---|
| container_issue | |
| container_start_page | 40 |
| container_title | Cancer letters |
| container_volume | 456 |
| creator | Kao, Yu-Yu Chou, Chung-Hsien Yeh, Li-Yin Chen, Yi-Fen Chang, Kuo-Wei Liu, Chung-Ji Fan Chiang, Chun-Yu Lin, Shu-Chun |
| description | MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms. This study investigates the disruptions of miR-31-SIRT3 cascade to explore their potential association with metabolic change in OSCC. We identified that miR-31 directly targeted SIRT3 in OSCC cells, and a reverse correlation between miR-31 expression and SIRT3 expression was noted in OSCC tumors. SIRT3 expression attenuated the miR-31 enhanced tumor cell migration and invasion. It also reduced the tumorigenic potential of FaDu cell line. miR-31-SIRT3 impaired the mitochondrial membrane potential and structural integrity. The dis-regulation of this axis also contributed to the genesis of oxidative stress. In addition, miR-31 switched tumor cells from aerobic metabolism to glycolytic metabolism. This study provides novel evidences demonstrating the presence of miR-31-mediated post-transcriptional regulation of SIRT3 in OSCC. The disruption of miR-31-SIRT3 cascade and the consequential metabolic aberrances are involved in OSCC progression.
•miR-31 targets SIRT3 to drive OSCC invasion.•OSCC tumors exhibit miR-31 upregulation and SIRT3 downregulation.•miR-31-SIRT3 disruption underlies the mitochondrial disturbance.•miR-31-SIRT3 cascade induces ROS, glycolytic metabolism and lactate production. |
| doi_str_mv | 10.1016/j.canlet.2019.04.028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2231952069</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383519302654</els_id><sourcerecordid>2226706730</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-2c66f00f1ceac428a1ec0784e520df8af87c955b143c46a46049a5041b2354b83</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0EotvCP0DIEhcuCePPOBekqiq0UgFpKWfL60zAqyRebKei_x5XWzhw4OTD-8w71jyEvGLQMmD63b71bpmwtBxY34JsgZsnZMNMx5uuN_CUbECAbIQR6oSc5rwHACU79ZycCAZKMcY2JH4KPsXt53M6h20jGC0ufceS6dfr7a2gJdIh5LQeSs1L9D_iMqTgJup8CXeh3FO3DDQsPqHLSOOvMLgaIM0lYc41oTFV3LvkwxJn94I8G92U8eXje0a-fbi8vbhqbr58vL44v2m8VLo03Gs9AozMo_OSG8fQQ2ckKg7DaNxoOt8rtWNSeKmd1CB7p0CyHRdK7ow4I2-PvYcUf66Yi51D9jhNbsG4Zsu5YH0t031F3_yD7uOalvq7SnHdge4EVEoeqXqunBOO9pDC7NK9ZWAfhNi9PQqxD0IsSFuF1LHXj-Xrbsbh79AfAxV4fwSwXuMuYLLZB1w8DiGhL3aI4f8bfgOf-50b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2226706730</pqid></control><display><type>article</type><title>MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kao, Yu-Yu ; Chou, Chung-Hsien ; Yeh, Li-Yin ; Chen, Yi-Fen ; Chang, Kuo-Wei ; Liu, Chung-Ji ; Fan Chiang, Chun-Yu ; Lin, Shu-Chun</creator><creatorcontrib>Kao, Yu-Yu ; Chou, Chung-Hsien ; Yeh, Li-Yin ; Chen, Yi-Fen ; Chang, Kuo-Wei ; Liu, Chung-Ji ; Fan Chiang, Chun-Yu ; Lin, Shu-Chun</creatorcontrib><description>MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms. This study investigates the disruptions of miR-31-SIRT3 cascade to explore their potential association with metabolic change in OSCC. We identified that miR-31 directly targeted SIRT3 in OSCC cells, and a reverse correlation between miR-31 expression and SIRT3 expression was noted in OSCC tumors. SIRT3 expression attenuated the miR-31 enhanced tumor cell migration and invasion. It also reduced the tumorigenic potential of FaDu cell line. miR-31-SIRT3 impaired the mitochondrial membrane potential and structural integrity. The dis-regulation of this axis also contributed to the genesis of oxidative stress. In addition, miR-31 switched tumor cells from aerobic metabolism to glycolytic metabolism. This study provides novel evidences demonstrating the presence of miR-31-mediated post-transcriptional regulation of SIRT3 in OSCC. The disruption of miR-31-SIRT3 cascade and the consequential metabolic aberrances are involved in OSCC progression.
•miR-31 targets SIRT3 to drive OSCC invasion.•OSCC tumors exhibit miR-31 upregulation and SIRT3 downregulation.•miR-31-SIRT3 disruption underlies the mitochondrial disturbance.•miR-31-SIRT3 cascade induces ROS, glycolytic metabolism and lactate production.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2019.04.028</identifier><identifier>PMID: 31055111</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Carcinoma ; Cell adhesion & migration ; Cell Line, Tumor ; Cell migration ; Cell Movement ; Dehydrogenases ; Disruption ; Energy Metabolism ; Epidermal growth factor ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Gene regulation ; Glycolysis ; Homeostasis ; Humans ; Male ; Medical prognosis ; Membrane potential ; Metabolism ; Mice, Nude ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; miR-31 ; miRNA ; Mitochondria ; Mitochondria - enzymology ; Mitochondria - pathology ; Mouth Neoplasms - enzymology ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; NAD ; Neoplasia ; Neoplasm Invasiveness ; Oral ; Oral cancer ; Oral carcinoma ; Oral squamous cell carcinoma ; Oxidative Stress ; Pathogenesis ; Phosphorylation ; Polymerase chain reaction ; Post-transcription ; Proteins ; Signal Transduction ; SIRT3 ; Sirtuin 3 - genetics ; Sirtuin 3 - metabolism ; Smoking ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - enzymology ; Squamous Cell Carcinoma of Head and Neck - genetics ; Squamous Cell Carcinoma of Head and Neck - pathology ; Tumor cells ; Tumors</subject><ispartof>Cancer letters, 2019-08, Vol.456, p.40-48</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>2019. Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-2c66f00f1ceac428a1ec0784e520df8af87c955b143c46a46049a5041b2354b83</citedby><cites>FETCH-LOGICAL-c456t-2c66f00f1ceac428a1ec0784e520df8af87c955b143c46a46049a5041b2354b83</cites><orcidid>0000-0001-9177-3647 ; 0000-0002-0385-869X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383519302654$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31055111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kao, Yu-Yu</creatorcontrib><creatorcontrib>Chou, Chung-Hsien</creatorcontrib><creatorcontrib>Yeh, Li-Yin</creatorcontrib><creatorcontrib>Chen, Yi-Fen</creatorcontrib><creatorcontrib>Chang, Kuo-Wei</creatorcontrib><creatorcontrib>Liu, Chung-Ji</creatorcontrib><creatorcontrib>Fan Chiang, Chun-Yu</creatorcontrib><creatorcontrib>Lin, Shu-Chun</creatorcontrib><title>MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms. This study investigates the disruptions of miR-31-SIRT3 cascade to explore their potential association with metabolic change in OSCC. We identified that miR-31 directly targeted SIRT3 in OSCC cells, and a reverse correlation between miR-31 expression and SIRT3 expression was noted in OSCC tumors. SIRT3 expression attenuated the miR-31 enhanced tumor cell migration and invasion. It also reduced the tumorigenic potential of FaDu cell line. miR-31-SIRT3 impaired the mitochondrial membrane potential and structural integrity. The dis-regulation of this axis also contributed to the genesis of oxidative stress. In addition, miR-31 switched tumor cells from aerobic metabolism to glycolytic metabolism. This study provides novel evidences demonstrating the presence of miR-31-mediated post-transcriptional regulation of SIRT3 in OSCC. The disruption of miR-31-SIRT3 cascade and the consequential metabolic aberrances are involved in OSCC progression.
•miR-31 targets SIRT3 to drive OSCC invasion.•OSCC tumors exhibit miR-31 upregulation and SIRT3 downregulation.•miR-31-SIRT3 disruption underlies the mitochondrial disturbance.•miR-31-SIRT3 cascade induces ROS, glycolytic metabolism and lactate production.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Carcinoma</subject><subject>Cell adhesion & migration</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Dehydrogenases</subject><subject>Disruption</subject><subject>Energy Metabolism</subject><subject>Epidermal growth factor</subject><subject>Female</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene regulation</subject><subject>Glycolysis</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Membrane potential</subject><subject>Metabolism</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miR-31</subject><subject>miRNA</subject><subject>Mitochondria</subject><subject>Mitochondria - enzymology</subject><subject>Mitochondria - pathology</subject><subject>Mouth Neoplasms - enzymology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>NAD</subject><subject>Neoplasia</subject><subject>Neoplasm Invasiveness</subject><subject>Oral</subject><subject>Oral cancer</subject><subject>Oral carcinoma</subject><subject>Oral squamous cell carcinoma</subject><subject>Oxidative Stress</subject><subject>Pathogenesis</subject><subject>Phosphorylation</subject><subject>Polymerase chain reaction</subject><subject>Post-transcription</subject><subject>Proteins</subject><subject>Signal Transduction</subject><subject>SIRT3</subject><subject>Sirtuin 3 - genetics</subject><subject>Sirtuin 3 - metabolism</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - enzymology</subject><subject>Squamous Cell Carcinoma of Head and Neck - genetics</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EotvCP0DIEhcuCePPOBekqiq0UgFpKWfL60zAqyRebKei_x5XWzhw4OTD-8w71jyEvGLQMmD63b71bpmwtBxY34JsgZsnZMNMx5uuN_CUbECAbIQR6oSc5rwHACU79ZycCAZKMcY2JH4KPsXt53M6h20jGC0ufceS6dfr7a2gJdIh5LQeSs1L9D_iMqTgJup8CXeh3FO3DDQsPqHLSOOvMLgaIM0lYc41oTFV3LvkwxJn94I8G92U8eXje0a-fbi8vbhqbr58vL44v2m8VLo03Gs9AozMo_OSG8fQQ2ckKg7DaNxoOt8rtWNSeKmd1CB7p0CyHRdK7ow4I2-PvYcUf66Yi51D9jhNbsG4Zsu5YH0t031F3_yD7uOalvq7SnHdge4EVEoeqXqunBOO9pDC7NK9ZWAfhNi9PQqxD0IsSFuF1LHXj-Xrbsbh79AfAxV4fwSwXuMuYLLZB1w8DiGhL3aI4f8bfgOf-50b</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Kao, Yu-Yu</creator><creator>Chou, Chung-Hsien</creator><creator>Yeh, Li-Yin</creator><creator>Chen, Yi-Fen</creator><creator>Chang, Kuo-Wei</creator><creator>Liu, Chung-Ji</creator><creator>Fan Chiang, Chun-Yu</creator><creator>Lin, Shu-Chun</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9177-3647</orcidid><orcidid>https://orcid.org/0000-0002-0385-869X</orcidid></search><sort><creationdate>20190801</creationdate><title>MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma</title><author>Kao, Yu-Yu ; Chou, Chung-Hsien ; Yeh, Li-Yin ; Chen, Yi-Fen ; Chang, Kuo-Wei ; Liu, Chung-Ji ; Fan Chiang, Chun-Yu ; Lin, Shu-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-2c66f00f1ceac428a1ec0784e520df8af87c955b143c46a46049a5041b2354b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Carcinoma</topic><topic>Cell adhesion & migration</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Dehydrogenases</topic><topic>Disruption</topic><topic>Energy Metabolism</topic><topic>Epidermal growth factor</topic><topic>Female</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene regulation</topic><topic>Glycolysis</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Membrane potential</topic><topic>Metabolism</topic><topic>Mice, Nude</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>miR-31</topic><topic>miRNA</topic><topic>Mitochondria</topic><topic>Mitochondria - enzymology</topic><topic>Mitochondria - pathology</topic><topic>Mouth Neoplasms - enzymology</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>NAD</topic><topic>Neoplasia</topic><topic>Neoplasm Invasiveness</topic><topic>Oral</topic><topic>Oral cancer</topic><topic>Oral carcinoma</topic><topic>Oral squamous cell carcinoma</topic><topic>Oxidative Stress</topic><topic>Pathogenesis</topic><topic>Phosphorylation</topic><topic>Polymerase chain reaction</topic><topic>Post-transcription</topic><topic>Proteins</topic><topic>Signal Transduction</topic><topic>SIRT3</topic><topic>Sirtuin 3 - genetics</topic><topic>Sirtuin 3 - metabolism</topic><topic>Smoking</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - enzymology</topic><topic>Squamous Cell Carcinoma of Head and Neck - genetics</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kao, Yu-Yu</creatorcontrib><creatorcontrib>Chou, Chung-Hsien</creatorcontrib><creatorcontrib>Yeh, Li-Yin</creatorcontrib><creatorcontrib>Chen, Yi-Fen</creatorcontrib><creatorcontrib>Chang, Kuo-Wei</creatorcontrib><creatorcontrib>Liu, Chung-Ji</creatorcontrib><creatorcontrib>Fan Chiang, Chun-Yu</creatorcontrib><creatorcontrib>Lin, Shu-Chun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kao, Yu-Yu</au><au>Chou, Chung-Hsien</au><au>Yeh, Li-Yin</au><au>Chen, Yi-Fen</au><au>Chang, Kuo-Wei</au><au>Liu, Chung-Ji</au><au>Fan Chiang, Chun-Yu</au><au>Lin, Shu-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>456</volume><spage>40</spage><epage>48</epage><pages>40-48</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>MicroRNA miR-31 is implicated in the neoplastic process of various malignancies including oral squamous cell carcinoma (OSCC). Silent information regulator 3 (Sirtuin3 or SIRT3) is a NAD-dependent deacetylase that regulates metabolic process. Suppressor role of SIRT3 has been found in neoplasms. This study investigates the disruptions of miR-31-SIRT3 cascade to explore their potential association with metabolic change in OSCC. We identified that miR-31 directly targeted SIRT3 in OSCC cells, and a reverse correlation between miR-31 expression and SIRT3 expression was noted in OSCC tumors. SIRT3 expression attenuated the miR-31 enhanced tumor cell migration and invasion. It also reduced the tumorigenic potential of FaDu cell line. miR-31-SIRT3 impaired the mitochondrial membrane potential and structural integrity. The dis-regulation of this axis also contributed to the genesis of oxidative stress. In addition, miR-31 switched tumor cells from aerobic metabolism to glycolytic metabolism. This study provides novel evidences demonstrating the presence of miR-31-mediated post-transcriptional regulation of SIRT3 in OSCC. The disruption of miR-31-SIRT3 cascade and the consequential metabolic aberrances are involved in OSCC progression.
•miR-31 targets SIRT3 to drive OSCC invasion.•OSCC tumors exhibit miR-31 upregulation and SIRT3 downregulation.•miR-31-SIRT3 disruption underlies the mitochondrial disturbance.•miR-31-SIRT3 cascade induces ROS, glycolytic metabolism and lactate production.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31055111</pmid><doi>10.1016/j.canlet.2019.04.028</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9177-3647</orcidid><orcidid>https://orcid.org/0000-0002-0385-869X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2019-08, Vol.456, p.40-48 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2231952069 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apoptosis Carcinoma Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Dehydrogenases Disruption Energy Metabolism Epidermal growth factor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene regulation Glycolysis Homeostasis Humans Male Medical prognosis Membrane potential Metabolism Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-31 miRNA Mitochondria Mitochondria - enzymology Mitochondria - pathology Mouth Neoplasms - enzymology Mouth Neoplasms - genetics Mouth Neoplasms - pathology NAD Neoplasia Neoplasm Invasiveness Oral Oral cancer Oral carcinoma Oral squamous cell carcinoma Oxidative Stress Pathogenesis Phosphorylation Polymerase chain reaction Post-transcription Proteins Signal Transduction SIRT3 Sirtuin 3 - genetics Sirtuin 3 - metabolism Smoking Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - enzymology Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Tumor cells Tumors |
| title | MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T03%3A08%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MicroRNA%20miR-31%20targets%20SIRT3%20to%20disrupt%20mitochondrial%20activity%20and%20increase%20oxidative%20stress%20in%20oral%20carcinoma&rft.jtitle=Cancer%20letters&rft.au=Kao,%20Yu-Yu&rft.date=2019-08-01&rft.volume=456&rft.spage=40&rft.epage=48&rft.pages=40-48&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2019.04.028&rft_dat=%3Cproquest_cross%3E2226706730%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2226706730&rft_id=info:pmid/31055111&rft_els_id=S0304383519302654&rfr_iscdi=true |