Expression analysis of a panel of long non-coding RNAs (lncRNAs) revealed their potential as diagnostic biomarkers in bladder cancer
Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis. In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnost...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2020-01, Vol.112 (1), p.677-682 |
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| creator | Abdolmaleki, Feraydoon Ghafoui-Fard, Soudeh Taheri, Mohammad Mordadi, Alireza Afsharpad, Mandana Varmazyar, Sajad Nazparvar, Bashir Oskooei, Vahid Kholghi Omrani, Mir Davood |
| description | Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis.
In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.
PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and |
| doi_str_mv | 10.1016/j.ygeno.2019.04.020 |
| format | Article |
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In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.
PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls (Expression ratios of 0.4, 0.68, 0.54 and 0.11; P values of 0.04, 0.02, 0.02 and <0.001 respectively).
Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%. The current study shows dysregulation of lncRNAs in bladder cancer and implies their role as diagnostic markers in this malignancy.
•We evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.•HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls.•GHET1 and HOTAIRM1 were significantly up-regulated in tumor tissues compared with normal controls.•Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%.•The current study shows dys-regulation of lncRNAs in bladder cancer and highlights their role as diagnostic markers in this malignancy.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/j.ygeno.2019.04.020</identifier><identifier>PMID: 31054930</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bladder cancer ; DLEU2 ; DSCAM-AS1 ; FAS-AS1 ; GHET1 ; HOTAIR ; HOTAIRM1 ; lncRNA ; NEAT1 ; THRIL ; TUG1</subject><ispartof>Genomics (San Diego, Calif.), 2020-01, Vol.112 (1), p.677-682</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-6ac35edc068b96a8eaab3ef7b8e8f6266cbec7b78b04fe8a75834314e74eadb3</citedby><cites>FETCH-LOGICAL-c359t-6ac35edc068b96a8eaab3ef7b8e8f6266cbec7b78b04fe8a75834314e74eadb3</cites><orcidid>0000-0002-0673-9717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygeno.2019.04.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31054930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdolmaleki, Feraydoon</creatorcontrib><creatorcontrib>Ghafoui-Fard, Soudeh</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><creatorcontrib>Mordadi, Alireza</creatorcontrib><creatorcontrib>Afsharpad, Mandana</creatorcontrib><creatorcontrib>Varmazyar, Sajad</creatorcontrib><creatorcontrib>Nazparvar, Bashir</creatorcontrib><creatorcontrib>Oskooei, Vahid Kholghi</creatorcontrib><creatorcontrib>Omrani, Mir Davood</creatorcontrib><title>Expression analysis of a panel of long non-coding RNAs (lncRNAs) revealed their potential as diagnostic biomarkers in bladder cancer</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis.
In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.
PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls (Expression ratios of 0.4, 0.68, 0.54 and 0.11; P values of 0.04, 0.02, 0.02 and <0.001 respectively).
Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%. The current study shows dysregulation of lncRNAs in bladder cancer and implies their role as diagnostic markers in this malignancy.
•We evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.•HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls.•GHET1 and HOTAIRM1 were significantly up-regulated in tumor tissues compared with normal controls.•Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%.•The current study shows dys-regulation of lncRNAs in bladder cancer and highlights their role as diagnostic markers in this malignancy.</description><subject>Bladder cancer</subject><subject>DLEU2</subject><subject>DSCAM-AS1</subject><subject>FAS-AS1</subject><subject>GHET1</subject><subject>HOTAIR</subject><subject>HOTAIRM1</subject><subject>lncRNA</subject><subject>NEAT1</subject><subject>THRIL</subject><subject>TUG1</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kDFvFDEQhS0EIkfgFyAhl6HYxV77dr0FRRQFghSBhNJbY3v28OGzF3svyvX8cHxcQkn1XvFm3sxHyFvOWs54_2HbHjYYU9sxPrZMtqxjz8iKMzU2qpf9c7JiSqlmWEtxRl6VsmWMjUJ1L8mZ4GwtR8FW5Pf1w5yxFJ8ihQjhUHyhaaJAZ4gYjjakuKExxcYm56v9_vWy0IsQ7dG8pxnvEQI6uvxAn-mcFoyLh0ChUOdhE1NZvKXGpx3kn5gL9ZGaAM5hphaixfyavJggFHzzqOfk7tP13dVNc_vt85ery9vGivW4ND1URWdZr8zYg0IAI3AajEI19V3fW4N2MIMyTE6oYFgrIQWXOEgEZ8Q5uTitnXP6tcey6J0vFkOon6Z90V0n-CgrM1Wj4hS1OZWScdJz9vX-g-ZMH-nrrf5LXx_payZ1pV-n3j0W7M0O3b-ZJ9w18PEUwPrlvcesi_VYETif0S7aJf_fgj-KjZmQ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Abdolmaleki, Feraydoon</creator><creator>Ghafoui-Fard, Soudeh</creator><creator>Taheri, Mohammad</creator><creator>Mordadi, Alireza</creator><creator>Afsharpad, Mandana</creator><creator>Varmazyar, Sajad</creator><creator>Nazparvar, Bashir</creator><creator>Oskooei, Vahid Kholghi</creator><creator>Omrani, Mir Davood</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0673-9717</orcidid></search><sort><creationdate>202001</creationdate><title>Expression analysis of a panel of long non-coding RNAs (lncRNAs) revealed their potential as diagnostic biomarkers in bladder cancer</title><author>Abdolmaleki, Feraydoon ; Ghafoui-Fard, Soudeh ; Taheri, Mohammad ; Mordadi, Alireza ; Afsharpad, Mandana ; Varmazyar, Sajad ; Nazparvar, Bashir ; Oskooei, Vahid Kholghi ; Omrani, Mir Davood</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-6ac35edc068b96a8eaab3ef7b8e8f6266cbec7b78b04fe8a75834314e74eadb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bladder cancer</topic><topic>DLEU2</topic><topic>DSCAM-AS1</topic><topic>FAS-AS1</topic><topic>GHET1</topic><topic>HOTAIR</topic><topic>HOTAIRM1</topic><topic>lncRNA</topic><topic>NEAT1</topic><topic>THRIL</topic><topic>TUG1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdolmaleki, Feraydoon</creatorcontrib><creatorcontrib>Ghafoui-Fard, Soudeh</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><creatorcontrib>Mordadi, Alireza</creatorcontrib><creatorcontrib>Afsharpad, Mandana</creatorcontrib><creatorcontrib>Varmazyar, Sajad</creatorcontrib><creatorcontrib>Nazparvar, Bashir</creatorcontrib><creatorcontrib>Oskooei, Vahid Kholghi</creatorcontrib><creatorcontrib>Omrani, Mir Davood</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdolmaleki, Feraydoon</au><au>Ghafoui-Fard, Soudeh</au><au>Taheri, Mohammad</au><au>Mordadi, Alireza</au><au>Afsharpad, Mandana</au><au>Varmazyar, Sajad</au><au>Nazparvar, Bashir</au><au>Oskooei, Vahid Kholghi</au><au>Omrani, Mir Davood</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression analysis of a panel of long non-coding RNAs (lncRNAs) revealed their potential as diagnostic biomarkers in bladder cancer</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>2020-01</date><risdate>2020</risdate><volume>112</volume><issue>1</issue><spage>677</spage><epage>682</epage><pages>677-682</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Long non-coding RNAs (lncRNAs) have fundamental roles in cell migration, proliferation, invasion and metastasis.
In the current study, we evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.
PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls (Expression ratios of 0.4, 0.68, 0.54 and 0.11; P values of 0.04, 0.02, 0.02 and <0.001 respectively).
Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%. The current study shows dysregulation of lncRNAs in bladder cancer and implies their role as diagnostic markers in this malignancy.
•We evaluated expression of a panel of lncRNAs in bladder cancer tissues, adjacent non-cancerous tissues (ANCTs) and normal bladder tissues to evaluate their diagnostic power.•HOTAIR, NEAT1, TUG1 and FAS-AS1 were significantly down-regulated in tumor tissues compared with normal controls.•GHET1 and HOTAIRM1 were significantly up-regulated in tumor tissues compared with normal controls.•Combination of transcript levels of seven lncRNAs improved both sensitivity and specificity values to 100%.•The current study shows dys-regulation of lncRNAs in bladder cancer and highlights their role as diagnostic markers in this malignancy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31054930</pmid><doi>10.1016/j.ygeno.2019.04.020</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0673-9717</orcidid></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Bladder cancer DLEU2 DSCAM-AS1 FAS-AS1 GHET1 HOTAIR HOTAIRM1 lncRNA NEAT1 THRIL TUG1 |
| title | Expression analysis of a panel of long non-coding RNAs (lncRNAs) revealed their potential as diagnostic biomarkers in bladder cancer |
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