Oral mucosa and salivary findings in non-diabetic patients with chronic kidney disease

•The prevalence of oral mucosa lesions/symptoms is higher in pre-dialysis patients.•The occurrence of oral symptoms is associated with significantly decreased ClCr.•Clinical and biochemical salivary parameters are significantly different between patients with CKD and healthy subjects.•Moderately strong positive correlation is obtained between serum and salivary creatinine. Chronic kidney disease (CKD) and dialysis treatment could affect oral mucosa and cause qualitative or quantitative changes of saliva. The aim of the study was to investigate oral manifestations, unstimulated salivary flow rate (USFR), salivary pH value and biochemical composition of saliva in non-diabetic patients with CKD. The study group (PD) consisted of 50 pre-dialysis patients diagnosed with CKD, positive control group (HD) of 25 haemodialysis patients and negative control (H) of 25 age and gender-matched healthy persons. Creatinine clearance rate (CrCl) was calculated from the blood creatinine using the Cockcroft-Gault formula. After a detailed intraoral examination, whole unstimulated saliva samples were collected to determine salivary pH value, and biochemical composition using a spectrophotometric method. Statistical analysis revealed that PD subjects had more oral lesions (p