Micellar liquid chromatography determination of rivaroxaban in plasma and urine. Validation and theoretical aspects

Micellar liquid chromatography determination of rivaroxaban in plasma and urine. Validation and theoretical aspects

A Micellar Chromatographic method to determine rivaroxaban in plasma and urine has been developed. The samples were dissolved in the mobile phase (SDS 0.05 M – 1-propanol 12.5%, phosphate buffered at pH 7) and 20 μL directly injected, avoiding the extraction and purification steps. Using a C18 colum...

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Veröffentlicht in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2019-07, Vol.1120, p.8-15
Hauptverfasser: Albiol-Chiva, Jaume, Peris-Vicente, Juan, García-Ferrer, Daniel, Esteve-Romero, Josep
Format: Artikel
Sprache:eng
Schlagworte:
Anticoagulant
Biological Fluid
Direct injection
Micellar Chromatography
Partition equilibrium
Validation
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Zusammenfassung:A Micellar Chromatographic method to determine rivaroxaban in plasma and urine has been developed. The samples were dissolved in the mobile phase (SDS 0.05 M – 1-propanol 12.5%, phosphate buffered at pH 7) and 20 μL directly injected, avoiding the extraction and purification steps. Using a C18 column and running under isocratic mode at 1 mL/min, analyte was eluted without interference from the matrix in
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2019.04.040