Effect of anti-fibroblast growth factor 23 antibody on phosphate and calcium metabolism in adenine gavaged laying hens

Dietary factors such as adenine have been linked to phosphate–calcium metabolism disturbance and adverse productive outcomes. Anti-fibroblast growth factor 23 (FGF-23) antibody has been proposed to ameliorate adenine-induced abnormal FGF23/phosphate metabolism. This experiment was conducted to inves...

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Veröffentlicht in:	Poultry science 2019-10, Vol.98 (10), p.4896-4900
Hauptverfasser:	Ren, Zhouzheng, Piepenburg, Alexis J, Yang, Xiaojun, Cook, Mark E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage adenine gavage Animal Feed - analysis Animal Nutritional Physiological Phenomena - drug effects Animals Autoantibodies - metabolism Calcium, Dietary - metabolism Chickens - immunology Chickens - metabolism Diet - veterinary Female FGF-23 antibody fibroblast growth factor 23 Fibroblast Growth Factors - metabolism kidney Nutritional Requirements - drug effects phosphate Phosphates - metabolism Phosphorus, Dietary - metabolism
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Beschreibung
Zusammenfassung:	Dietary factors such as adenine have been linked to phosphate–calcium metabolism disturbance and adverse productive outcomes. Anti-fibroblast growth factor 23 (FGF-23) antibody has been proposed to ameliorate adenine-induced abnormal FGF23/phosphate metabolism. This experiment was conducted to investigate the application of anti-FGF-23 antibody in adenine-gavaged laying hens. Single Comb White Leghorn laying hens with (n = 10) or without (control group, n = 10) systemic anti-FGF-23 antibody were orally gavaged with adenine (600 mg/hen/D) for 21 consecutive days. Adenine gavage increased (P ≤ 0.01) plasma phosphate and calcium levels and tended to increase (0.05
ISSN:	0032-5791 1525-3171
DOI:	10.3382/ps/pez239