Visible-Light Induction/Brønsted Acid Catalysis in Relay for the Enantioselective Synthesis of Tetrahydroquinolines

Visible-Light Induction/Brønsted Acid Catalysis in Relay for the Enantioselective Synthesis of Tetrahydroquinolines

An efficient method merging Brønsted acid catalysis with visible-light induction for the highly enantioselective synthesis of tetrahydroquinolines has been developed. This mild process directly transforms 2-aminoenones into 2-substituted tetrahydroquinolines with excellent enantioselectivities throu...

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Veröffentlicht in:Organic letters 2019-06, Vol.21 (11), p.4173-4176
Hauptverfasser: Xiong, Wenhui, Li, Shan, Fu, Bo, Wang, Jinping, Wang, Qiu-An, Yang, Wen
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient method merging Brønsted acid catalysis with visible-light induction for the highly enantioselective synthesis of tetrahydroquinolines has been developed. This mild process directly transforms 2-aminoenones into 2-substituted tetrahydroquinolines with excellent enantioselectivities through a relay visible-light-induced cyclization/chiral phosphoric acid-catalyzed transfer hydrogenation reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01354