The combination of swimming and curcumin consumption may improve spatial memory recovery after binge ethanol drinking

Helping the return of people with social disorders, including ethanol consumption, are important research topics in the field of biological sciences, and there are many uncertainties about the efficacy of drug interventions and exercise training. The aim of this study was to investigate the effects short-term combination of curcumin and swimming on the improvement of spatial memory. Male Wistar rats (200–250 g) were randomly assigned into ethanol or dextrose groups. After 4 days of gavage, and withdrawn of consumption, they were affected by swimming intervention or curcumin supplementation within 2 weeks. Spatial memory was assessed in Morris Water Maze (MWM) apparatus by a single training session of eight trials. Furthermore, levels of BDNF were measured in hippocampal tissue by doing real time PCR. The results showed that binge ethanol drinking had no significant effect on the traveled distance [F(1,14) = 0.024; P > .05] and escape latency [F(1,14) = 0.648; P > .05] of reaching the platform. In the probe test, both the percentage of swimming time [t(14) = −4.621; P