Role of Phosphorylcholine-Specific Immunoglobulin M in Acute Upper Respiratory Tract Infections
Objectives: The aim of this study was to clarify the role of serum phosphorylcholine (PC)–specific immunoglobulin M (IgM) as a natural antibody against infectious diseases. Methods: The relationship between serum PC-specific IgM level and C-reactive protein level or white blood cell counts was exami...
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Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2019-06, Vol.128 (6_suppl), p.111S-116S |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objectives:
The aim of this study was to clarify the role of serum phosphorylcholine (PC)–specific immunoglobulin M (IgM) as a natural antibody against infectious diseases.
Methods:
The relationship between serum PC-specific IgM level and C-reactive protein level or white blood cell counts was examined in patients with severe upper respiratory tract infections (ie, acute epiglottitis and peritonsillar abscess).
Results:
PC-specific IgM level was significantly negatively correlated with C-reactive protein level and white blood cell count. In addition, C-reactive protein level and white blood cell count was significantly lower in women than in men, whereas PC-specific IgM level was significantly higher in women.
Conclusions:
PC-specific IgM is suggested to have protective and suppressive effects against the progression of infectious and inflammatory reactions. Higher levels of PC-specific IgM in women might be one of the reasons why the incidence and severity of acute epiglottitis and peritonsillar abscess are lower in women. |
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ISSN: | 0003-4894 1943-572X |
DOI: | 10.1177/0003489419835568 |