Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma

Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma

Regulatory T cells (Tregs) and tumour-associated macrophages (TAMs) contribute to the tumour microenvironment by inhibiting anti-tumour immune responses. This study was performed to investigate the roles of Tregs and TAMs in oral squamous cell carcinoma (OSCC) and oral epithelial precursor lesions (...

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Veröffentlicht in:International journal of oral and maxillofacial surgery 2019-10, Vol.48 (10), p.1279-1288
Hauptverfasser: Kouketsu, A., Sato, I., Oikawa, M., Shimizu, Y., Saito, H., Tashiro, K., Yamashita, Y., Takahashi, T., Kumamoto, H.
Format: Artikel
Sprache:eng
Schlagworte:
Dentistry
oral cancer
oral epithelial precursor lesions
regulatory T cell
squamous cell carcinoma
tumour-associated macrophage
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Zusammenfassung:Regulatory T cells (Tregs) and tumour-associated macrophages (TAMs) contribute to the tumour microenvironment by inhibiting anti-tumour immune responses. This study was performed to investigate the roles of Tregs and TAMs in oral squamous cell carcinoma (OSCC) and oral epithelial precursor lesions (OEPL). The expression of Treg markers CD25 and FoxP3 and TAM markers CD163 and CD204 was investigated in 82 OSCC and 45 OEPL specimens, and their associations with clinicopathological parameters were analyzed. Correlations were found among CD25, FoxP3, CD163, and CD204 levels (P 
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2019.04.004