rs895819 in microRNA-27a increase stomach neoplasms risk in China: A meta-analysis

Across the globe, gastric cancer is a significant public health problem. This meta-analysis was conducted to investigate the association of microRNA-27a (miRNA-27a) rs895819 with gastric cancer risk. The search of databases updated on October 10, 2018 included Pubmed, Embase, Cochrane Library and Web of science. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to assess the risk of tumor. Overall meta-analysis suggested the miRNA-27a rs895819 was not related to the gastric carcinogenesis among all model including allele contrast (G vs A, pooled OR: 1.096, 95% CI: 0.962–1.249, P = 0.196), codominant model (GG vs AA, pooled OR: 1.124, 95% CI: 0.794–1.592, P = 0.590; AG vs AA, pooled OR: 1.101, 95% CI: 0.966–1.217, P = 0.060), dominant model (AG + GG vs AA, pooled OR: 1.123, 95% CI: 0.964–1.307, P = 0.136) and recessive model (GG vs AG + AA, pooled OR: 0.927, 95% CI: 0.673–1.278, P = 0.644). Interestingly, among different ethnicity group, significant relation between rs895819 and gastric cancer was observed in co-dominant model among Chinese population (AG vs AA, pooled OR: 1.158, 95% CI: 1.038–1.291, P = 0.008) but not some regions of European population (AG vs AA, pooled OR: 0.852, 95% CI: 0.632–1.148, P = 0.179). Our results find that rs895819 contributed to occurrence of gastric cancer in co-dominant model in Chinese population. •Rs895819 genotype (AG vs AA) might increase risk of stomach neoplasms among Chinese population.•Rs895819 genotype using sequencing was related to increased risk of stomach neoplasms under co-dominant and dominant models.•Updated articles were included in our work to draw effective conclusion on this issue which made our study more convincing.