The effect of dopamine on response inhibition in Parkinson's disease relates to age-dependent patterns of nigrostriatal degeneration

Motor but also non-motor effects are modulated by dopamine (DA) in Parkinson's disease (PD). Impaired inhibition has been related to dopamine overdosing of the associative striatum. We compared effects of dopaminergic medication on inhibitory control in patients with young (age at onset

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Bibliographische Detailangaben
Veröffentlicht in:	Parkinsonism & related disorders 2019-06, Vol.63, p.185-190
Hauptverfasser:	Kübler, Dorothee, Schroll, Henning, Hamker, Fred H., Joutsa, Juho, Buchert, Ralph, Kühn, Andrea A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Computer Simulation Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Corpus Striatum - pathology Corpus Striatum - physiopathology Dopamine overdose hypothesis Dopamine Plasma Membrane Transport Proteins - metabolism Female FP-CIT SPECT Humans Inhibition Inhibition, Psychological Male Middle Aged Parkinson Disease - diagnostic imaging Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - physiopathology Psychomotor Performance - physiology Striatum Substantia Nigra - diagnostic imaging Substantia Nigra - metabolism Substantia Nigra - pathology Substantia Nigra - physiopathology Tomography, Emission-Computed, Single-Photon Tropanes Young and late onset Parkinson's disease
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Beschreibung
Zusammenfassung:	Motor but also non-motor effects are modulated by dopamine (DA) in Parkinson's disease (PD). Impaired inhibition has been related to dopamine overdosing of the associative striatum. We compared effects of dopaminergic medication on inhibitory control in patients with young (age at onset
ISSN:	1353-8020 1873-5126
DOI:	10.1016/j.parkreldis.2019.02.003