Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study

Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study

Objectives To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes. Method A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinica...

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Veröffentlicht in:Clinical rheumatology 2019-06, Vol.38 (6), p.1665-1673
Hauptverfasser: Hong, Yan, Shi, Pengxian, Liu, Xia, Yang, Liu, Li, Kang, Xu, Feng, Liang, Shaoshan, Liu, Zhengzhao, Zhang, Haitao, Chen, Yinghua, Hu, Weixin
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology
Antibodies, Antineutrophil Cytoplasmic - immunology
Antineutrophil cytoplasmic antibodies
Female
Fluorescent Antibody Technique, Indirect
Glomerulonephritis
Glomerulonephritis - immunology
Granulomatosis
Humans
Kidney - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Myeloblastin - immunology
Original Article
Peroxidase - immunology
Recurrence
Retrospective Studies
Rheumatology
Serotypes
Skin
Survival
Vasculitis
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Zusammenfassung:Objectives To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes. Method A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. Results In this study, 429 (91.9%) patients tested positive for MPO-ANCA, and 38 (8.1%) for PR3-ANCA. The median age at diagnosis ( P  = 0.017) and proportion of females ( P  = 0.003) were higher in the MPO group. Joint ( P  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-019-04458-9