Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with kainic acid-induced seizures

Epileptogenesis is a dynamic process initiated by insults to brain and commonly accompanied by cognitive impairment. Isoliquiritigenin (ISL), a flavonoid in licorice, has a broad spectrum of biological effects including anti-inflammatory and antioxidant activities. However, the protective effects of...

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Veröffentlicht in:	International immunopharmacology 2019-07, Vol.72, p.358-366
Hauptverfasser:	Zhu, Xiaobo, Liu, Jiankun, Huang, Shanying, Zhu, Weiwei, Wang, Yibiao, Chen, Ou, Xue, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants Astrocytes Biological effects Brain Brain injury Brain-derived neurotrophic factor Caspase Caspase-1 Caspase-3 Chalcones - pharmacology Chalcones - therapeutic use Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Cognitive impairment Convulsions & seizures Cytokines Encephalitis - drug therapy Encephalitis - metabolism Epilepsy Epileptogenesis Glial cells Glial plasticity Hippocampus - drug effects Hippocampus - metabolism Impairment Inflammasomes Inflammasomes - metabolism Inflammation Injection Interleukin 18 Isoliquiritigenin Kainic Acid Latency Localization Lymphocytes B Male Microglia NAD NADPH quinone oxidoreductase Neuronal-glial interactions Neurons - drug effects Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-E2-Related Factor 2 - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pretreatment of water Proteins Quinones Rat Rats, Wistar Seizures Seizures - chemically induced Seizures - drug therapy Seizures - metabolism Signaling Synapses - drug effects
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