Optimization of the reduction of 74As(V) to 74As(III) and of the labelling of dithiol dihydrolipoic acid

The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized. •Optimization of the circumstances of reduction of As(V).•New HPLC method for As(III)/As(V) separation.•Optimization of labelling process between As(III) and dithiol complex agent.