EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10

EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10

EphA8 is a member of the erythropoietin‐producing hepatocellular receptor (Eph) family of receptor tyrosine kinases. Ephs and their ephrins ligands play crucial roles in many cellular processed by mediating intracellular signaling resulting from cell–cell interactions. But the underlying mechanisms...

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Veröffentlicht in:Journal of cellular physiology 2019-11, Vol.234 (11), p.20408-20419
Hauptverfasser: Wang, Yingjing, Zhou, Nan, Li, Peng, Wu, Han, Wang, Qingqing, Gao, Xiaodong, Wang, Xudong, Huang, Jianfei
Format: Artikel
Sprache:eng
Schlagworte:
ADAM10
AKT protein
Cancer
Cell interactions
Cell migration
Cell proliferation
Cyclin A
Cyclin D1
Diagnostic systems
EphA8
Ephrins
Erythropoietin
Gastric cancer
Gelatinase A
Gelatinase B
Intracellular signalling
Kinases
Matrix metalloproteinase
Matrix metalloproteinases
Medical prognosis
Metastases
Metastasis
Oncogenes
Prognosis
Proteins
Ribonucleic acid
Risk analysis
Risk factors
RNA
Therapeutic applications
Tyrosine
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Zusammenfassung:EphA8 is a member of the erythropoietin‐producing hepatocellular receptor (Eph) family of receptor tyrosine kinases. Ephs and their ephrins ligands play crucial roles in many cellular processed by mediating intracellular signaling resulting from cell–cell interactions. But the underlying mechanisms of EphA8 in gastric cancer (GC) remains unclearly. 298 clinical specimens in tissues microarray, and was found to be significantly higher in GC tissues compared with nontumor tissues (p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28642