Optimal timing of hepatitis B virus DNA quantification and clinical predictors for higher viral load during pregnancy

Optimal timing of hepatitis B virus DNA quantification and clinical predictors for higher viral load during pregnancy

Introduction Authorities publish recommendations on the hepatitis B virus (HBV) viral load threshold to initiate antiviral treatment but the timing of quantification during pregnancy is not well defined. HBV DNA levels in pregnancy women at 28‐30 weeks predict the risk of immunoprophylaxis failure....

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Veröffentlicht in:Acta obstetricia et gynecologica Scandinavica 2019-10, Vol.98 (10), p.1301-1306
Hauptverfasser: Cheung, Ka W., Seto, Mimi T. Y., So, Po L., Wong, Daniel, Mak, Annisa S. L., Lau, Wai L., Wang, Weilan, Kan, Anita S. Y., Lee, Chin P., Ng, Ernest H. Y.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antiretroviral drugs
Antiviral drugs
Deoxyribonucleic acid
DNA
DNA, Viral - analysis
Female
Hepatitis
Hepatitis B
Hepatitis B - drug therapy
Hepatitis B Vaccines - administration & dosage
hepatitis B virus
Hepatitis B virus - genetics
Hong Kong
Hospitals, Public
Humans
Immunization
Infant, Newborn
infectious disease transmission, vertical
Infectious Disease Transmission, Vertical - prevention & control
Pregnancy
Pregnancy Complications, Infectious - virology
Pregnancy Trimester, Second
Prospective Studies
Retrospective Studies
Risk Factors
Viral Load
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Zusammenfassung:Introduction Authorities publish recommendations on the hepatitis B virus (HBV) viral load threshold to initiate antiviral treatment but the timing of quantification during pregnancy is not well defined. HBV DNA levels in pregnancy women at 28‐30 weeks predict the risk of immunoprophylaxis failure. This study compared and evaluated the correlation between HBV DNA levels before 22 and 28‐30 weeks’ gestation. Clinical predictive factors for HBV DNA >6, 7 and 8 log10 IU/mL were studied. Material and methods A retrospective analysis of HBV DNA levels of women
ISSN:0001-6349
1600-0412
DOI:10.1111/aogs.13631