Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats

Nowadays, medicinal plants have been widely used everywhere to provide essential care for many disorders including diabetes. Recent reports assumed that the antidiabetic activities of pomegranate aril juice (PAJ) may be ascribed to its punicalagin (PCG). Therefore, the present study evaluated and co...

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Veröffentlicht in:	Molecular biology reports 2019-08, Vol.46 (4), p.3701-3711
Hauptverfasser:	El-Beih, Nadia M., Ramadan, Gamal, El-Husseiny, Enas A., Hussein, Aya M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animals Antioxidants Antioxidants - metabolism Biomedical and Life Sciences Blood Glucose - metabolism Body weight Body Weight - drug effects Body weight loss c-Jun protein Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Histology Hydrolyzable Tannins - administration & dosage Hydrolyzable Tannins - metabolism Hydrolyzable Tannins - therapeutic use Hyperglycemia Hyperglycemia - drug therapy Insulin Insulin Receptor Substrate Proteins - drug effects Insulin Resistance JNK Mitogen-Activated Protein Kinases - drug effects JNK protein Life Sciences Lipid peroxidation Lipid Peroxidation - drug effects Liver Liver - drug effects Liver - metabolism Liver - pathology Male Medicinal plants Morphology Muscle, Skeletal - drug effects Niacinamide - administration & dosage Niacinamide - metabolism Nicotinamide Nitric oxide Nitric Oxide - metabolism Original Article Pomegranate - metabolism Rats Rodents Skeletal muscle Streptozocin Streptozocin - administration & dosage Streptozocin - metabolism Transcription factors Tumor Necrosis Factor-alpha - drug effects Tumor necrosis factor-α
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Zusammenfassung:	Nowadays, medicinal plants have been widely used everywhere to provide essential care for many disorders including diabetes. Recent reports assumed that the antidiabetic activities of pomegranate aril juice (PAJ) may be ascribed to its punicalagin (PCG). Therefore, the present study evaluated and compared the antidiabetic activities of PAJ and its PCG, and monitored some mechanisms of their actions in streptozotocin-nicotinamide (STZ-NA) type 2 diabetic rats. STZ-NA diabetic rats were given, orally/daily, PAJ (100 or 300 mg/kg body weight, containing 2.6 and 7.8 mg of PCG/kg body weight, respectively), pure PCG (2.6 or 7.8 mg/kg body weight), or distilled water (vehicle) for 6 weeks. PAJ (especially at the high dose) alleviated significantly ( P
ISSN:	0301-4851 1573-4978
DOI:	10.1007/s11033-019-04813-8