Significance of survivin mRNA blood levels in patients with melanoma

Survivin represents a key anti-apoptotic molecule that is highly expressed in the vast majority of tumors. The aim of the study was to examine the significance of survivin mRNA blood levels in melanoma patients. In this prospective translational research study, survivin mRNA blood levels were measur...

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Veröffentlicht in:	Journal of B.U. ON. 2018-12, Vol.23 (7), p.96-103
Hauptverfasser:	Samarkos, Michael, Papaxoinis, George, Athanasoula, Kalliopi, Benopoulou, Οlga, Bouros, Spyros, Anastasopoulou, Amalia, Diamantopoulos, Panagiotis, Gogas, Helen, Mantzourani, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Case-Control Studies Female Follow-Up Studies Humans Male Melanoma - blood Melanoma - genetics Melanoma - pathology Middle Aged Prognosis Prospective Studies RNA, Messenger - blood RNA, Messenger - genetics Survival Rate Survivin - blood Survivin - genetics Young Adult
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Zusammenfassung:	Survivin represents a key anti-apoptotic molecule that is highly expressed in the vast majority of tumors. The aim of the study was to examine the significance of survivin mRNA blood levels in melanoma patients. In this prospective translational research study, survivin mRNA blood levels were measured in melanoma patients treated with adjuvant interferon or systemic treatment for advanced disease. Sixty-four patients with melanoma and 40 healthy controls were included. The majority of them had tumor stages III and IV. The upper 95% confidence interval (95%CI) of survivin levels in controls was set as normal cut-off. Fifty-two (81.3%) patients had survivin levels above normal cut-off. Melanoma patients had higher survivin levels than controls (p
ISSN:	1107-0625