Lipase‐Powered Mesoporous Silica Nanomotors for Triglyceride Degradation

Lipase‐Powered Mesoporous Silica Nanomotors for Triglyceride Degradation

We report lipase‐based nanomotors that are capable of enhanced Brownian motion over long periods of time in triglyceride solution and of degrading triglyceride droplets that mimic “blood lipids”. We achieved about 40 min of enhanced diffusion of lipase‐modified mesoporous silica nanoparticles (MSNPs...

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Veröffentlicht in:Angewandte Chemie International Edition 2019-06, Vol.58 (24), p.7992-7996
Hauptverfasser: Wang, Lei, Hortelão, Ana C., Huang, Xin, Sánchez, Samuel
Format: Artikel
Sprache:eng
Schlagworte:
Biodegradation
Biomedical materials
Brownian motion
Diffusion coefficient
Droplets
Enhanced diffusion
Environmental degradation
enzyme nanomotors
Lipase
Lipids
micromotors
Nanoparticles
oil removal
Oil spills
self-propulsion
Silica
Silicon dioxide
Substrates
Triacetin
Triglycerides
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Beschreibung
Zusammenfassung:We report lipase‐based nanomotors that are capable of enhanced Brownian motion over long periods of time in triglyceride solution and of degrading triglyceride droplets that mimic “blood lipids”. We achieved about 40 min of enhanced diffusion of lipase‐modified mesoporous silica nanoparticles (MSNPs) through a biocatalytic reaction between lipase and its corresponding water‐soluble oil substrate (triacetin) as fuel, which resulted in an enhanced diffusion coefficient (ca. 50 % increase) at low triacetin concentration (
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201900697