Prognostic analysis of amyotrophic lateral sclerosis based on clinical features and plasma surface‐enhanced Raman spectroscopy

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a wide range of survival times. We aimed to explore prognostic factors related to short survival based on clinical features and plasma metabolic signatures using surface‐enhanced Raman spectroscopy (SERS). One hundred and...

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Veröffentlicht in:	Journal of biophotonics 2019-08, Vol.12 (8), p.e201900012-n/a
Hauptverfasser:	Zhang, Qi‐Jie, Chen, Yang, Zou, Xiao‐Huan, Hu, Wei, Lin, Xue‐Liang, Feng, Shang‐Yuan, Chen, Fa, Xu, Liu‐Qing, Chen, Wan‐Jin, Wang, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amyotrophic lateral sclerosis Antioxidants Biosynthesis Body mass index Body size Galactose Glutathione Medical prognosis Metabolic pathways Metabolism Multivariate analysis Neurodegenerative diseases Neurological diseases Nucleic acids Phenylalanine prognosis Raman spectroscopy Spectroscopy Spectrum analysis surface‐enhanced Raman spectroscopy Survival Therapeutic applications Tryptophan Tyrosine Uric acid
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Zusammenfassung:	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a wide range of survival times. We aimed to explore prognostic factors related to short survival based on clinical features and plasma metabolic signatures using surface‐enhanced Raman spectroscopy (SERS). One hundred and thirty‐eight sporadic ALS cases were enrolled serially, including 62 for the short‐duration group (≤3 years) and 76 for the long‐duration group (>3 years). Multivariate analysis showed that an older age of onset (>60 years; odds ratio [OR] = 3.98, 95% CI: 1.09‐14.53), lower body mass index (BMI) (
ISSN:	1864-063X 1864-0648
DOI:	10.1002/jbio.201900012