Extremely low therapeutic doses of acenocoumarol in a patient with CYP2C93/3 and VKORC1-1639A/A genotype

Vitamin-K antagonists (VKAs) have remained the mainstay of oral anticoagulant therapy for the treatment and prevention of thromboembolism. The management of treatment with VKAs is challenging due to their narrow therapeutic index and the wide interindividual variation in response to therapy. Variants of the and the gene account for 30-50% of the variability in dosing requirements, and it has been proposed that genotyping of these loci could facilitate management of VKA therapy and minimize risk of overanticoagulation, even in very low doses. We present the first reported case of a patient with the compounded genotype and under treatment with acenocoumarol, and review of other reported cases with analogous genotypic profiles but under treatment with warfarin.