Inhibitory effect of polysaccharide of Sargassum weizhouense on PCV2 induced inflammation in mice by suppressing histone acetylation

Porcine circovirus type 2 PCV2 mediate the equilibrium between HATs and HDACs, alternate the histone acetylation and thus DNA packaging, and then activate the transcription of inflammatory cytokines, resulting in inflammatory injury. polysaccharide of Sargassum weizhouense could interfere such alternations in PCV2-infected animals and show potentials in improving the resistance of host against PCV2 infection. [Display omitted] •Polysaccharide of Sargassum weizhouense (PSW) inhibits the production of inflammaory cytokines in PCV2 infected mice.•PSW modulates the equilibrium between activities of histone acetyltransferases and deacetylases.•PSW inhibits histone acetylation in infected mice. Seaweeds are excellent source of bioactive compounds and seaweed-derived polysaccharides have demonstrated an array of biological effects. Here, we investigated the effect of polysaccharide of Sargassum weizhouense (PSW) on the inflammatory response in porcine circovirus type 2 (PCV2) infected mice and the underlying mechanism was studied according to the histone acetylation. After PCV2 infection, the levels of TNF-α, IL-1β, IL-6, IL-8, IL-10, MCP-1, COX-1, COX-2 and HAT in both serum and spleen were significantly increased (P