Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms

Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms

•Vitamin D deficiency is common in the Middle East.•Response to Vitamin D supplementation is genetically influenced.•SNPs in GC gene can predict response to vitamin D supplementation.•Carriers of rs4588/rs7041 in GC had lowest response to vitamin D supplementation. The aim of this study was to deter...

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Veröffentlicht in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2019-07, Vol.63-64, p.148-154
Hauptverfasser: Al-Daghri, Nasser M., Mohammed, Abdul Khader, Bukhari, Ihtisham, Rikli, Maryam, Abdi, Saba, Ansari, Mohammed Ghouse Ahmed, Sabico, Shaun, Hussain, Syed Danish, Alenad, Amal, Al-Saleh, Yousef, Alokail, Majed S.
Format: Artikel
Sprache:eng
Schlagworte:
25(OH)D
Alleles
Bioavailability
Body mass index
Body size
Deoxyribonucleic acid
Dietary supplements
Disease
DNA
Enzymes
Family medical history
Genotypes
Men
Metabolites
Polymerase chain reaction
Proteins
rs4588
rs7041
Single-nucleotide polymorphism
Vitamin D
Vitamin D supplement
Vitamin D-binding protein
Vitamin deficiency
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Zusammenfassung:•Vitamin D deficiency is common in the Middle East.•Response to Vitamin D supplementation is genetically influenced.•SNPs in GC gene can predict response to vitamin D supplementation.•Carriers of rs4588/rs7041 in GC had lowest response to vitamin D supplementation. The aim of this study was to determine the influence of vitamin D–binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2019.02.003