Interrupting Toxoplasma’s Regularly Scheduled Program of Egress

Interrupting Toxoplasma’s Regularly Scheduled Program of Egress

Although many cellular components of the Ca2+ signaling pathway dictating Toxoplasma gondii egress have been identified, whether the parasite secretes protein activators of this pathway remained unknown. Bisio et al. (Nat. Microbiol. 2019;4:420–428) identify a parasite-secreted diacylglycerol kinase...

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Veröffentlicht in:Trends in parasitology 2019-05, Vol.35 (5), p.338-340
1. Verfasser: Carruthers, Vern B.
Format: Artikel
Sprache:eng
Schlagworte:
Ca2+ signaling
Guanylate Cyclase
parasite egress
Phosphatidic Acids
Signal Transduction
Toxoplasma
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Zusammenfassung:Although many cellular components of the Ca2+ signaling pathway dictating Toxoplasma gondii egress have been identified, whether the parasite secretes protein activators of this pathway remained unknown. Bisio et al. (Nat. Microbiol. 2019;4:420–428) identify a parasite-secreted diacylglycerol kinase as a key upstream activator of signaling for ‘programmed' egress from host cells.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2019.03.007