UNC93B1 promotes tumoral growth by controlling the secretion level of granulocyte macrophage colony-stimulating factor in human oral cancer

Unc-93 homolog B1 (UNC93B1), a transmembrane protein, is correlated with immune diseases, such as influenza, herpes simplex encephalitis, and the pathogenesis of systemic lupus erythematosus; however, the role of UNC93B1 in cancers including human oral squamous cell carcinomas (OSCCs) remains unknow...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-05, Vol.513 (1), p.81-87
Hauptverfasser:	Wagai, Sho, Kasamatsu, Atsushi, Iyoda, Manabu, Hayashi, Fumihiko, Hiroshima, Kazuya, Yoshimura, Shusaku, Miyamoto, Isao, Nakashima, Dai, Endo-Sakamoto, Yosuke, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Cycle Checkpoints Cell Line, Tumor Cell-cycle arrest at G1 phase Cells, Cultured Gene Expression Regulation, Neoplastic GM-CSF Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Humans Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology OSCC Tumoral growth UNC93B1
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Zusammenfassung:	Unc-93 homolog B1 (UNC93B1), a transmembrane protein, is correlated with immune diseases, such as influenza, herpes simplex encephalitis, and the pathogenesis of systemic lupus erythematosus; however, the role of UNC93B1 in cancers including human oral squamous cell carcinomas (OSCCs) remains unknown. In the current study, we investigated the UNC93B1expression level in OSCCs using quantitative reverse transcription-polymerase chain reaction, immunoblot analysis, and immunohistochemistry. Our data showed that UNC93B1 mRNA and protein expressions increased markedly (p
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2019.03.172