Efficient siRNA delivery with non-cationic carriers

Efficient siRNA delivery with non-cationic carriers

Self-assembled weakly negative nanoparticles bearing an octet of short interfering RNAs, targeting ligands and endosomolytic peptides lead to efficient gene silencing in a mouse model of prostate cancer.

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Bibliographische Detailangaben
Veröffentlicht in:Nature biomedical engineering 2018-05, Vol.2 (5), p.275-276
Hauptverfasser: Choi, Chun Kit K., Zhang, Lei, Choi, Chung Hang Jonathan
Format: Artikel
Sprache:eng
Schlagworte:
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Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Drug Carriers
Gene silencing
Nanoparticles
News & Views
news-and-views
Peptides
Prostate cancer
Ribonucleoproteins
RNA, Small Interfering
Self-assembly
siRNA
Transfection
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Beschreibung
Zusammenfassung:Self-assembled weakly negative nanoparticles bearing an octet of short interfering RNAs, targeting ligands and endosomolytic peptides lead to efficient gene silencing in a mouse model of prostate cancer.
ISSN:2157-846X
2157-846X
DOI:10.1038/s41551-018-0240-z