Supraphysiologic parenteral ascorbic acid blunts the inflammatory mediator response to pathogen associated molecular patterns in dogs ex vivo

Supraphysiologic parenteral ascorbic acid blunts the inflammatory mediator response to pathogen associated molecular patterns in dogs ex vivo

•There was a significant increase in TNF production after LPS, LTA, and PG compared to placebo.•Parenteral administration of ascorbic acid resulted in significantly increased plasma concentrations of ascorbic acid.•High dose parenteral ascorbic acid administration significantly reduced plasma concen...

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Veröffentlicht in:Research in veterinary science 2019-06, Vol.124, p.228-232
Hauptverfasser: Deitschel, S.J., Harmon, M., Odunayo, A., Chang, C., Honaker, A.R., DeClue, A.E.
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Ascorbic acid
Cytokines
Cytotoxicity
Dogs
Dosage
Free radicals
Gram-positive bacteria
Illnesses
Inflammation
Interleukin 6
Kinases
Laboratories
Leukocytes
Metabolism
Oxidative stress
Pathogens
Sepsis
Signal transduction
Time response
Tumor necrosis factor
Veterinary medicine
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Zusammenfassung:•There was a significant increase in TNF production after LPS, LTA, and PG compared to placebo.•Parenteral administration of ascorbic acid resulted in significantly increased plasma concentrations of ascorbic acid.•High dose parenteral ascorbic acid administration significantly reduced plasma concentrations of TNF and IL-6.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2019.03.006