Ontogeny of cytokine responses to PHA from birth to adulthood

Ontogeny of cytokine responses to PHA from birth to adulthood

Background Altered production of cytokines is believed to contribute to early childhood susceptibility to infection. The aim of this study was to get further insight into the developmental patterns of cytokine responses from birth to adulthood. Methods The expression levels of 13 cytokines were comp...

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Veröffentlicht in:Pediatric research 2019-07, Vol.86 (1), p.63-70
Hauptverfasser: Jeljeli, Mohamed, Guérin-El Khourouj, Valérie, Pédron, Béatrice, Gressens, Pierre, Sibony, Olivier, Sterkers, Ghislaine
Format: Artikel
Sprache:eng
Schlagworte:
Basic Science Article
Cytokines
Developmental biology
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Proteins
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Zusammenfassung:Background Altered production of cytokines is believed to contribute to early childhood susceptibility to infection. The aim of this study was to get further insight into the developmental patterns of cytokine responses from birth to adulthood. Methods The expression levels of 13 cytokines were compared in the supernatants of phytohemaggluttinin (PHA)-stimulated whole blood from healthy neonates (cord blood, n  = 8), infants ( 
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-019-0383-y