Impact of ∼omics in the detection and validation of potential anti-infective drugs

[Display omitted] •The antibiotics pipeline is lacking development from academia and industry.•∼Omics technologies advanced the anti-infectives discoveries of the last decades.•Data analysis and databases are essential for making new discoveries. New anti-infective drugs are an unmet necessity of modern medicine. The use of ∼omics technologies has exponentially increased the knowledge on active anti-infective structures, where to search for them and their mechanisms of action. Research involving extreme and unique environments (such as endophytes) revealed their potential for many yet unknown active molecules. This work intends to review a recent research involving discovery of secondary metabolites with an established anti-infective action which was mediated by one of the ∼omics sciences: genomics, proteomics, transcriptomics, metabolomics, glycomics or their combinations, as well as the software at the base of these discoveries.