Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines

The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protec...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (31), p.4519-4522
Hauptverfasser:	Huo, Chang-Xin, Dhara, Debashis, Baliban, Scott M, Tahmasebi Nick, Setare, Tan, Zibin, Simon, Raphael, Misra, Anup Kumar, Huang, Xuefei
Format:	Artikel
Sprache:	eng
Schlagworte:	Allolevivirus - chemistry Allolevivirus - immunology Animals Antibodies Antibodies, Bacterial - immunology Antibodies, Bacterial - therapeutic use Antigens Carbohydrates Glycan Immunoglobulin G - immunology Immunoglobulin G - therapeutic use Immunology Mice O Antigens - chemistry O Antigens - immunology O Antigens - metabolism Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - immunology Salmonella Salmonella enteritidis - metabolism Salmonella enteritidis - pathogenicity Salmonella Infections, Animal - mortality Salmonella Infections, Animal - prevention & control Salmonella Infections, Animal - therapy Salmonella Vaccines - immunology Survival Rate Vaccines Vaccines, Virus-Like Particle - chemistry Vaccines, Virus-Like Particle - immunology
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Beschreibung
Zusammenfassung:	The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c8cc08622b