Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies
Objectives Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. Methods A number of databases were used to gather relevant info...
Gespeichert in:
Veröffentlicht in: | Clinical rheumatology 2019-08, Vol.38 (8), p.2053-2061 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 2061 |
---|---|
container_issue | 8 |
container_start_page | 2053 |
container_title | Clinical rheumatology |
container_volume | 38 |
creator | Qiu, Xiao-juan Zhang, Xiu-ling Cai, Lai-sheng Yan, Chen Yu, Le Fan, Jie Zhang, Rong-wei Huang, Jing-wei Duan, Xin-wang |
description | Objectives
Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis.
Methods
A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed.
Results
A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without.
Conclusion
Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety. |
doi_str_mv | 10.1007/s10067-019-04502-8 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2200768582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2198877202</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-b5fa6c16d6d73e6714f3bcea83b736821966525be9abe39e76e110bdc8bcda973</originalsourceid><addsrcrecordid>eNp9kEtLxDAQx4Mouj6-gAcpePESnSRtHt5EfOGCIHoOaTt1u263a5KC--3Nuj7Ag5dMYH7zH-ZHyCGDUwagzkJ6paLADIW8AE71BhmxXOTUmNxskhEoBVQwo3fIbghTAODasG2yI8DwHBiMyP3jBIfOxb6tM-fjxLexDZmb15lvw2vWN-n_3mJcnmcu6zA66uZutgwJSr2qn_Q-ZiEOdYthn2w1bhbw4Kvukefrq6fLWzp-uLm7vBjTKs9ZpGXROFkxWctaCZSK5Y0oK3RalEpIzZmRsuBFicaVKAwqiYxBWVe6rGpnlNgjJ-vche_fBgzRdm2ocDZzc-yHYDlPdqQuNE_o8R902g8-XZCo5EUrxWFF8TVV-T4Ej41d-LZzfmkZ2JVqu1Ztk2r7qdrqNHT0FT2UHdY_I99uEyDWQEit-Qv6393_xH4AYcqI2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2198877202</pqid></control><display><type>article</type><title>Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Qiu, Xiao-juan ; Zhang, Xiu-ling ; Cai, Lai-sheng ; Yan, Chen ; Yu, Le ; Fan, Jie ; Zhang, Rong-wei ; Huang, Jing-wei ; Duan, Xin-wang</creator><creatorcontrib>Qiu, Xiao-juan ; Zhang, Xiu-ling ; Cai, Lai-sheng ; Yan, Chen ; Yu, Le ; Fan, Jie ; Zhang, Rong-wei ; Huang, Jing-wei ; Duan, Xin-wang</creatorcontrib><description>Objectives
Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis.
Methods
A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed.
Results
A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without.
Conclusion
Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-019-04502-8</identifier><identifier>PMID: 30924010</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Anxiety ; Anxiety - complications ; Anxiety - epidemiology ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - psychology ; Cohort analysis ; Cohort Studies ; Humans ; Incidence ; Medicine ; Medicine & Public Health ; Meta-analysis ; Odds Ratio ; Original Article ; Rheumatoid arthritis ; Rheumatology ; Risk Factors ; Sensitivity analysis</subject><ispartof>Clinical rheumatology, 2019-08, Vol.38 (8), p.2053-2061</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2019</rights><rights>Clinical Rheumatology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-b5fa6c16d6d73e6714f3bcea83b736821966525be9abe39e76e110bdc8bcda973</citedby><cites>FETCH-LOGICAL-c441t-b5fa6c16d6d73e6714f3bcea83b736821966525be9abe39e76e110bdc8bcda973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-019-04502-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-019-04502-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30924010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Xiao-juan</creatorcontrib><creatorcontrib>Zhang, Xiu-ling</creatorcontrib><creatorcontrib>Cai, Lai-sheng</creatorcontrib><creatorcontrib>Yan, Chen</creatorcontrib><creatorcontrib>Yu, Le</creatorcontrib><creatorcontrib>Fan, Jie</creatorcontrib><creatorcontrib>Zhang, Rong-wei</creatorcontrib><creatorcontrib>Huang, Jing-wei</creatorcontrib><creatorcontrib>Duan, Xin-wang</creatorcontrib><title>Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objectives
Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis.
Methods
A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed.
Results
A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without.
Conclusion
Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.</description><subject>Anxiety</subject><subject>Anxiety - complications</subject><subject>Anxiety - epidemiology</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - psychology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Odds Ratio</subject><subject>Original Article</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kEtLxDAQx4Mouj6-gAcpePESnSRtHt5EfOGCIHoOaTt1u263a5KC--3Nuj7Ag5dMYH7zH-ZHyCGDUwagzkJ6paLADIW8AE71BhmxXOTUmNxskhEoBVQwo3fIbghTAODasG2yI8DwHBiMyP3jBIfOxb6tM-fjxLexDZmb15lvw2vWN-n_3mJcnmcu6zA66uZutgwJSr2qn_Q-ZiEOdYthn2w1bhbw4Kvukefrq6fLWzp-uLm7vBjTKs9ZpGXROFkxWctaCZSK5Y0oK3RalEpIzZmRsuBFicaVKAwqiYxBWVe6rGpnlNgjJ-vche_fBgzRdm2ocDZzc-yHYDlPdqQuNE_o8R902g8-XZCo5EUrxWFF8TVV-T4Ej41d-LZzfmkZ2JVqu1Ztk2r7qdrqNHT0FT2UHdY_I99uEyDWQEit-Qv6393_xH4AYcqI2Q</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Qiu, Xiao-juan</creator><creator>Zhang, Xiu-ling</creator><creator>Cai, Lai-sheng</creator><creator>Yan, Chen</creator><creator>Yu, Le</creator><creator>Fan, Jie</creator><creator>Zhang, Rong-wei</creator><creator>Huang, Jing-wei</creator><creator>Duan, Xin-wang</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190801</creationdate><title>Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies</title><author>Qiu, Xiao-juan ; Zhang, Xiu-ling ; Cai, Lai-sheng ; Yan, Chen ; Yu, Le ; Fan, Jie ; Zhang, Rong-wei ; Huang, Jing-wei ; Duan, Xin-wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-b5fa6c16d6d73e6714f3bcea83b736821966525be9abe39e76e110bdc8bcda973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anxiety</topic><topic>Anxiety - complications</topic><topic>Anxiety - epidemiology</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - psychology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Odds Ratio</topic><topic>Original Article</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Sensitivity analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Xiao-juan</creatorcontrib><creatorcontrib>Zhang, Xiu-ling</creatorcontrib><creatorcontrib>Cai, Lai-sheng</creatorcontrib><creatorcontrib>Yan, Chen</creatorcontrib><creatorcontrib>Yu, Le</creatorcontrib><creatorcontrib>Fan, Jie</creatorcontrib><creatorcontrib>Zhang, Rong-wei</creatorcontrib><creatorcontrib>Huang, Jing-wei</creatorcontrib><creatorcontrib>Duan, Xin-wang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Xiao-juan</au><au>Zhang, Xiu-ling</au><au>Cai, Lai-sheng</au><au>Yan, Chen</au><au>Yu, Le</au><au>Fan, Jie</au><au>Zhang, Rong-wei</au><au>Huang, Jing-wei</au><au>Duan, Xin-wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>38</volume><issue>8</issue><spage>2053</spage><epage>2061</epage><pages>2053-2061</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objectives
Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis.
Methods
A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed.
Results
A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without.
Conclusion
Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.</abstract><cop>London</cop><pub>Springer London</pub><pmid>30924010</pmid><doi>10.1007/s10067-019-04502-8</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0770-3198 |
ispartof | Clinical rheumatology, 2019-08, Vol.38 (8), p.2053-2061 |
issn | 0770-3198 1434-9949 |
language | eng |
recordid | cdi_proquest_miscellaneous_2200768582 |
source | MEDLINE; Springer Nature - Complete Springer Journals |
subjects | Anxiety Anxiety - complications Anxiety - epidemiology Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - psychology Cohort analysis Cohort Studies Humans Incidence Medicine Medicine & Public Health Meta-analysis Odds Ratio Original Article Rheumatoid arthritis Rheumatology Risk Factors Sensitivity analysis |
title | Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T23%3A46%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rheumatoid%20arthritis%20and%20risk%20of%20anxiety:%20a%20meta-analysis%20of%20cohort%20studies&rft.jtitle=Clinical%20rheumatology&rft.au=Qiu,%20Xiao-juan&rft.date=2019-08-01&rft.volume=38&rft.issue=8&rft.spage=2053&rft.epage=2061&rft.pages=2053-2061&rft.issn=0770-3198&rft.eissn=1434-9949&rft_id=info:doi/10.1007/s10067-019-04502-8&rft_dat=%3Cproquest_cross%3E2198877202%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2198877202&rft_id=info:pmid/30924010&rfr_iscdi=true |