Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies

Objectives Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. Methods A number of databases were used to gather relevant info...

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Veröffentlicht in:Clinical rheumatology 2019-08, Vol.38 (8), p.2053-2061
Hauptverfasser: Qiu, Xiao-juan, Zhang, Xiu-ling, Cai, Lai-sheng, Yan, Chen, Yu, Le, Fan, Jie, Zhang, Rong-wei, Huang, Jing-wei, Duan, Xin-wang
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container_end_page 2061
container_issue 8
container_start_page 2053
container_title Clinical rheumatology
container_volume 38
creator Qiu, Xiao-juan
Zhang, Xiu-ling
Cai, Lai-sheng
Yan, Chen
Yu, Le
Fan, Jie
Zhang, Rong-wei
Huang, Jing-wei
Duan, Xin-wang
description Objectives Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. Methods A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed. Results A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without. Conclusion Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.
doi_str_mv 10.1007/s10067-019-04502-8
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Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. Methods A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed. Results A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without. Conclusion Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-019-04502-8</identifier><identifier>PMID: 30924010</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Anxiety ; Anxiety - complications ; Anxiety - epidemiology ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - psychology ; Cohort analysis ; Cohort Studies ; Humans ; Incidence ; Medicine ; Medicine &amp; Public Health ; Meta-analysis ; Odds Ratio ; Original Article ; Rheumatoid arthritis ; Rheumatology ; Risk Factors ; Sensitivity analysis</subject><ispartof>Clinical rheumatology, 2019-08, Vol.38 (8), p.2053-2061</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2019</rights><rights>Clinical Rheumatology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-b5fa6c16d6d73e6714f3bcea83b736821966525be9abe39e76e110bdc8bcda973</citedby><cites>FETCH-LOGICAL-c441t-b5fa6c16d6d73e6714f3bcea83b736821966525be9abe39e76e110bdc8bcda973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-019-04502-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-019-04502-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30924010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Xiao-juan</creatorcontrib><creatorcontrib>Zhang, Xiu-ling</creatorcontrib><creatorcontrib>Cai, Lai-sheng</creatorcontrib><creatorcontrib>Yan, Chen</creatorcontrib><creatorcontrib>Yu, Le</creatorcontrib><creatorcontrib>Fan, Jie</creatorcontrib><creatorcontrib>Zhang, Rong-wei</creatorcontrib><creatorcontrib>Huang, Jing-wei</creatorcontrib><creatorcontrib>Duan, Xin-wang</creatorcontrib><title>Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objectives Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. Methods A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed. Results A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without. 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Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. Methods A number of databases were used to gather relevant information; they included PubMed, EMBASE, and Web of Science, with the publication date of articles limited up to July 23, 2018. To evaluate their association, an odds ratio (OR) with 95% confidence interval (CI) was used. The random-effects model played a crucial role in calculating the pooled odds ratio, while subgroup analyses and sensitivity analyses were also performed. Results A total of 10 studies, including 6201 cases of anxiety and 139,875 participants, met our inclusion criteria for this meta-analysis. All individuals were without anxiety at baseline. The follow-up period ranged from 1.0 to 9.2 years. Overall, the quantitative meta-analysis suggested that subjects with RA were associated with a significantly increased risk of anxiety incidence (OR, 1.20; 95% CI, 1.03–1.39) than those without. Conclusion Results of this meta-analysis indicate that individuals with RA may confer an increased risk for the development of anxiety. Future studies should explore whether clinical manifestations of RA are modifiable risk factors for anxiety.</abstract><cop>London</cop><pub>Springer London</pub><pmid>30924010</pmid><doi>10.1007/s10067-019-04502-8</doi><tpages>9</tpages></addata></record>
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subjects Anxiety
Anxiety - complications
Anxiety - epidemiology
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - psychology
Cohort analysis
Cohort Studies
Humans
Incidence
Medicine
Medicine & Public Health
Meta-analysis
Odds Ratio
Original Article
Rheumatoid arthritis
Rheumatology
Risk Factors
Sensitivity analysis
title Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies
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