Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells

Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2019-08, Vol.166 (2), p.163-173
Hauptverfasser:	Yasukochi, Atsushi, Kawakubo-Yasukochi, Tomoyo, Morioka, Masahiko, Hazekawa, Mai, Nishinakagawa, Takuya, Ono, Kazuhiko, Nakashima, Manabu, Nakamura, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantigens - genetics Autoantigens - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Collagen Type XVII Humans MicroRNAs - metabolism Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Non-Fibrillar Collagens - genetics Non-Fibrillar Collagens - metabolism Polymerase Chain Reaction Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.
ISSN:	0021-924X 1756-2651
DOI:	10.1093/jb/mvz024